Out today in @Nature : nature.com/articles/s4158… - some steps toward understanding cell-to-cell genomic variation in cancer. Joint work with @sajraparicio lab (now 15yr collab!). Work performed by @tylerfunnell @marcjwills_ @oflanach and teams from both labs. We studied how different background endogenous mutational processes impact individual cell genomes in cancer. Events in single cells represent to a first approximation the most recent alterations and so reflect the true diversity upon which selection can act.

Studying cellular fitness and evolution in polyclonal human cancers has been a challenge due to lack of scaled single cell time series analysis. Advances in this area achieved together with @sajraparicio lab were published online in @nature today: nature.com/articles/s4158… 1/12 Credit is due to an enduring wet-dry collaboration between labs led by 2 newly minted PhDs Dr. Sohrab Salehi @GreedyApple and Dr. Farhia Kabeer @farhia_kabeer. 2/12