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Steven Brem Profile picture
Steven Brem
@StevenBremMD
Professor of Neurosurgery at the University of Pennsylvania, neurosurgeon, scientist, innovator, advancing clinical trials to meet unmet needs in neuro-oncology
Jan 22, 2023 • 5 tweets • 3 min read
Delighted that the Editorial Board of @NeurologyToday, the news source of the AAN, @AANmember, selected our dendritic cell vaccine trial, led by Dr. Linda Liau, as one of the "Best Advances of 2022." #immunotherapy @PennNeurology @PennNSG @PennCancer

pubmed.ncbi.nlm.nih.gov/36394838/ The article notes Median OS for 232 patients with nGBM on DCVax = 19.3M from randomization (22.4M from surgery) vs 16.5M from controls; Survival at 48 M = 15.7% vs 9.9%; mOS at 60M, 13.0M vs 5.7%. Survival for 64 patients with rGBM =13.2M vs. 7.8 M, controls. At 24M, 20.7 vs 9.6%
Jan 20, 2023 • 7 tweets • 4 min read
An urgent unmet need in neuro-oncology is a quantitative, non-invasive biomarker that can track and quantitate the heterogeneous, infiltrative, peritumoral microenvironment. Excited by the elegant, AI-based report of DiCIPHR Lab & CBICA, now in @SciReports
pubmed.ncbi.nlm.nih.gov/36653382/ Kudos to the authors, an interdisciplinary "Dream Team" from @PennRadiology, @PennNSG, engineering, informatics, working to advance the Penn Brain Tumor Center. Zahra Riahi Samani is the f...Pictured are Drew Parker (l...Ronald L. Wolf (left) and S...Spyridon (Spyros) Bakas (le...