Q. Has ChatGPT just given the game away?

With this Unholy Trinity of microRNAs!

miR-19a-3p

miR-21-5p

miR-142-3p

Please read on for some interesting answers. All 3 were shown to be ⬆️

So, let’s Kickoff with miR-19a-3p.

What is it’s role?

Why might 3 little letters UGA be important in Covid and Cancer?

Many have highlighted the key role the amino acid Trp plays in SARS-CoV2 infection

However, I have not seen mention that the UGA codon for many bacteria and mitochondria, can code for Trp rather than a Stop Codon. UGA is also connected to the production of selenocysteine, considered to be the 21st genetically encoded amino acid!

L.selenocysteine has played an important evolutionary role in Oxidoreductase reactions - or, more simply - electron/energy transfers!

biorxiv.org/content/10.110…

This paper hypothesise’s:

H. Pylori causes gastric cancer by➡️⬇️ E-Cadherin & p53

Normally ⬇️ E-cadherin ➡️ ⬆️cellular stress ➡️ activation p53

However, in HP infection there is ⬇️ p53 + inactivation.

How?

Via HDM2 - a negative regulator of p53.

pubmed.ncbi.nlm.nih.gov/25605238/ Under normal conditions, p53 expression is maintained at a low level, whereas under stress conditions, this negative regulation is alleviated to ⬆️ p53, to allow the “guardian of the genome” to fulfill its role!

So, ⬇️ HDM2 ➡️⬆️ p53

pubmed.ncbi.nlm.nih.gov/31023026/

Can they hide IL-35?

IL-35 is an immunosuppressive IL-12 family cytokine that contains a p35 subunit and the EBI3 subunit. It is secreted by Treg and effector T cells.

And, regulates the balance of Th17 and Treg in many diseases

pubmed.ncbi.nlm.nih.gov/32918357/

https://twitter.com/agenervt/status/1597451231836110848

For example, connective tissue diseases like SLE and dermatomyositis - which I have previously discussed in connection with the SP - here ⬇️

https://twitter.com/teamsforlife/status/1510925457126043652

This paper predicts miR-21-5p is ⬆️

Thereby reducing inflammation and symptoms.

crimsonpublishers.com/aics/pdf/AICS.…

https://twitter.com/teamsforlife/status/1595076169262665729

This is hardly surprising given that the Spike Protein has 2 potential binding sites for miR-21 and would be viewed as a stressor to the cell.

https://twitter.com/teamsforlife/status/1392149958372085763

The Twin Towers of Covid - Energy & Information!

Loss of Energy and Misinformation - Generating Entropy & Inflammation!

This Energy transfer is from the cell/mitochondria to the SP and involves electrostatic forces and REDOX reactions producing free radicals/ionising radiation. The element that is essential for life and is central to both energy and information, because of its role in ATP DNA/RNA & Phospholipids -

Phosphorous.

It’s name is derived from the Greek for light-bearer and Latin word Lucifer.

This study from the University of Melbourne claims to have found the miRNA Signature of Covid

Amazingly out of all the 1000s of miRNAs just 3 were needed to classify COVID cases with a 99.9% accuracy!

The holy trinity were; miR-195, miR-23 & miR-423

journals.plos.org/plospathogens/… These bioinformatics could provide very useful clues to the pathogenesis of COVID.

Two of the miRNAs (miR-195 & miR-423) were significantly elevated, whereas miR-23 was only marginally increased.

miR-195 dysregulation is related to the pathogenesis of many diseases.