Family Doctor - Some people think football is a matter of life or death - I just think it’s LIFE (Love,Inspire,Faith,Energy). Play Well and Keep in Shape!
Jan 24 • 17 tweets • 7 min read
Q. Has ChatGPT just given the game away?
With this Unholy Trinity of microRNAs!
Please read on for some interesting answers.
All 3 were shown to be ⬆️
So, let’s Kickoff with miR-19a-3p.
What is it’s role?
Jan 23 • 24 tweets • 10 min read
Why might 3 little letters UGA be important in Covid and Cancer?
Many have highlighted the key role the amino acid Trp plays in SARS-CoV2 infection
However, I have not seen mention that the UGA codon for many bacteria and mitochondria, can code for Trp rather than a Stop Codon.
UGA is also connected to the production of selenocysteine, considered to be the 21st genetically encoded amino acid!
L.selenocysteine has played an important evolutionary role in Oxidoreductase reactions - or, more simply - electron/energy transfers!
However, in HP infection there is ⬇️ p53 + inactivation.
Via HDM2 - a negative regulator of p53.
Under normal conditions, p53 expression is maintained at a low level, whereas under stress conditions, this negative regulation is alleviated to ⬆️ p53, to allow the “guardian of the genome” to fulfill its role!
Loss of Energy and Misinformation - Generating Entropy & Inflammation!
This Energy transfer is from the cell/mitochondria to the SP and involves electrostatic forces and REDOX reactions producing free radicals/ionising radiation.
The element that is essential for life and is central to both energy and information, because of its role in ATP DNA/RNA & Phospholipids -
It’s name is derived from the Greek for light-bearer and Latin word Lucifer.
Feb 14, 2022 • 12 tweets • 5 min read
This study from the University of Melbourne claims to have found the miRNA Signature of Covid
Amazingly out of all the 1000s of miRNAs just 3 were needed to classify COVID cases with a 99.9% accuracy!