What regulates the impact of diet on #health and #longevity? The first two preprints from our collaboration with @jacksonlab and @Calico reveal surprising interactions between #diet, #genetics, and #microbiome in #aging. (1/12)



biorxiv.org/content/10.110…
biorxiv.org/content/10.110… We followed close to 1,000 genetically diverse mice over the lifespan. These mice underwent four different types of dietary interventions (fasting and caloric restriction), were extensively phenotyped, and their microbiomes were sequenced at regular intervals. (2/12)

We are excited to share our new work @Nature, led by @Lenka_Dohnal, uncovering a gut-brain pathway that regulates the motivation for #exercise. (1/7)

nature.com/articles/s4158… We assessed the exercise capacity of a large cohort of deeply-profiled genetically-diverse mice and identified the gut #microbiome as an important contributor to exercise performance. (2/7)