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This reports on an ambitious 5-year project to begin addressing fundamental cog. neuroscience questions with a generative/mechanistic approach. The key was to take our activity flow approach (colelab.github.io/ActflowToolbox/) to the next level by modeling both cognition & behavior. 2/n
We realized even if all neurons' functions were mapped we still wouldn't know how the brain worked. Same goes for mapping all connections (connectome). We propose combining functional & connectivity maps, using predictive network models as "glue": network coding models. (2/7)
Cognition emerges from network interactions, such that causal interactions should be central to studying brain function. Yet the research closest to this – functional connectivity – focuses primarily on association (correlation/coherence) rather than causation.
An alternate link to the paper is on our lab's website: colelab.org/#publications