Knees regrow like you're 20 again?

New drug MF-300 blocks aging enzyme to fix arthritis for good.

Thread time 🧵 Cartilage is the soft, squishy padding between your knee bones. It protects them when you walk or run.

As we age, this cushion wears thin.

That causes osteoarthritis (OA), which results in painful swelling and stiffness in joints.

What if a 4–amino acid peptide could ‘remind’ your cells how to be young?

Epitalon is a synthetic tetrapeptide derived from pineal extracts, studied for effects on telomerase, melatonin, and age-related physiology in humans and animals.

It behaves like a pineal signal that may nudge aging cells back toward youthful programs. A peptide that turns telomerase back on… friend or foe?

In vitro data show Epitalon can activate telomerase and lengthen telomeres in human cell lines, extending their replicative lifespan beyond the classic Hayflick limit.

Huge upside for cellular aging, but with theoretical oncologic risk if abused

A new drug in the middle of clinical trials just increased REM sleep by 90% without making people sleep longer!

This is the first medication ever to specifically enhance REM only and the implications go far beyond seizure control.

Here's what just happened. 🧵 This past week (Jan 6, 2026), Bright Minds Biosciences announced Phase 2 results for BMB-101:

• 73.1% reduction in absence seizures (p=0.012, statistically significant)

• 63.3% reduction in major motor seizures (developmental epilepsy)

• 90% increase in REM sleep (56.2 → 106.7 minutes)

Total sleep duration: unchanged

These patients had failed a median of 3-10 other treatments for seizure control