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330 AD - Due to the Eastern half of the empire being more populated and prosperous compared to the stagnating Western half, and due to it's strategic location for defense and trade, connecting Asia with Europe, Constantine makes Constantinople the new capital of the Roman Empire. 
George MacDonald is often credited as being the first fantasy author.

Think of a hammer. There’s a reason why hammer design hasn't changed much.
Ancient Rome had a military horseman class, but in the so-called Dark Ages or Migration Period in Late Antiquity, knights didn’t quite exist yet.
Galen, Aristotle and Avicenna were great contributors to the corpus of the medieval understanding of humoral theory.