New👇concerning study of covid vax safety in kids
All data from randomized trials
17,538 in vax group
8011 in placebo
Vax group had

◾️3.8 x⬆️risk of severe adverse events (5-17yrs)

◾️3x⬆️risk of lower respiratory infection(6m-5yrs)

We never had data to rec vax 4 all kids

https://twitter.com/StabellBenn/status/1733094332029137333

Bravo to two of my best friends, @StabellBenn & #ramduriseti. Brilliant idea for a study. 👏

Our @CDCDirector is reciting US govt propaganda
-omitting incidental hospitalization rates
-omitting better @JAMACardio data finding post vax myocarditis 6-28x higher than post covid in 16-24 yo males
-omitting the fact no European countries recommend the new vax for healthy kids

https://twitter.com/CDCDirector/status/1705349114190295043

@CDCDirector @JAMACardio Here is the study in @JAMACardio with better data from the Nordic countries about post vaccination myocarditis and my tweet going over the math

https://twitter.com/TracyBethHoeg/status/1583303306218127361

Sigh

@US_FDA just approved Pfizer vax ABRYSVO in pregnancy to protect infants against RSV despite a 20%! higher rate of preterm birth in vax group (5.7%) vs controls (4.7%)

Most of VRBPAC shrugged off signal as "non significant" but study underpowered🧵
investors.pfizer.com/Investors/News…
Here's the MATISSE study, the basis of the VRBPAC approval

Table above from this (non open access) study

Pfizer in the VRBPAC meeting said all they would've needed to determine if preterm birth signal real was enroll 5,000 instead of 3,600 in each arm🤦‍♀️
nejm.org/doi/full/10.10…

Just...wow. How is this @JAMANetworkOpen article on supposed "misinformation" spread by physicians not parody?
I outline in this🧵9 of the more egregious false claims made by the authors

Study should be retracted; it's an embarrassment to our profession jamanetwork.com/journals/jaman… ❌Here the article cites the flawed Data Tracker for death count that doesn't use death certificates & has repeatedly overcounted deaths in children, as we described in our paper ()
CDC Wonder put deaths from (not with COVID) at around 980,000 as of 7/2023. https://t.co/v3hCpuZgbjpapers.ssrn.com/sol3/papers.cf…

Our correspondence is out in @njem written w @VPrasadMDMPH & Ram Duriseti

We show v strong evidence of healthy vaccinee bias in an Israeli study of Pfizer booster vs covid death, which wasn't disclosed

Could explain ALL reported benefit of the booster🧵
https://t.co/b29YQ0lblhnejm.org/doi/full/10.10…
This bias may apply to all similar studies from Israel's Clalit Health Services

This
Highlights the importance of data transparency (their data aren't made publicly available, thus findings can't be re-analyzed)
&
Highlights the importance of providing data on all cause deaths

Is @CDCMMWR a reliable journal for informing health policy?

In a new paper Alyson Haslam @VPrasadMDMPH & I analyze 77 MMWR reports pertaining to masks

Our results were concerning

>75% concluded masks were effective
w/only 30% testing masks
0 were RCTs🧵
https://t.co/PwL1pcdlhVmedrxiv.org/content/10.110…
We show select additional characteristics of the studies in Figure 1

None cited randomized studies of masks

98.8% did not cite conflicting evidence re masks

>75% concluded masks were effective w/<15% having statistically significant results

Over 50% used causal language

This story & the one being run today in @WSJ:
How would it be possible the 3 researchers infected in November 2019 were the "1st to be infected" when serological evidence indicates covid was circulating in Europe in early fall 2019?
link.springer.com/article/10.100…
journals.sagepub.com/doi/10.1177/03…

https://twitter.com/shellenberger/status/1668660948532625410

My understanding from virologists is the presence of the furin cleavage site is v strong evidence covid was the result of gof research but I don't think calling these 3 scientists "patients 0" is accurate/helpful. Glad lab leak's being investigated, though
wsj.com/articles/u-s-f…

In this 🧵 I look at the evidence behind many of the statements @RobertKennedyJr made on @joerogan re vaccine safety in the first 60 minutes of the show.

Both "sides" may be surprised by my conclusions

Though we sometimes disagree, I like RFK, Jr

Let me know what I got wrong ✅The Danish study mentioned by @RobertKennedyJr of the DPT vax & infant mortality (note my friend, @StabellBenn an author) was IMO a very convincing natural experiment.
DTP vax WAS associated with 5x higher mortality in infants; 10x higher in girls. ncbi.nlm.nih.gov/pmc/articles/P…

Well, here we are📍

Obs study, but even adjusting for testing & most recent infection, healthcare employees who had received a bivalent booster (in pink, by testing propensity) were more likely to test + for COVID(XBB) than those who hadn't

& some still want vax mandates?
See🧵 twitter.com/i/web/status/1… Link to study: medrxiv.org/content/10.110…

I see I need to clarify:

In addition to the 8 SCD due to post-vax myo in the Korean study, there were 13 additional deaths due to fulminant post-vax myo
=21 total post-vax deaths+ 1❤️ transplant

I modified their table to show this
Of the 13, 7 female, 5d1, 5d2, 6 post pfizer twitter.com/i/web/status/1… More about the 13 clinical myo deaths
Ages 24-95
2 were booster doses!
3 after AZ

I realized even though I said there were 21 total deaths in my thread yesterday and I focused on the 8 autopsy proven SCD due to myo, many thought the total post-vax myo death count was 8.
Sorry!

Preparing my congressional testimony & I'm curious if anyone can provide me w/statistics & a reference/references about what % or $ amount of CDC's funding comes from the pharmaceutical industry.
Grateful to @akheriaty who was the first one to teach me about the CDC Foundation.

https://twitter.com/akheriaty/status/1519004863169896450

@akheriaty I heard my friend @RobertKennedyJr mention @US_FDA gets 50% of its budget from pharma on @unherd. Was wondering what his source was for this & Robert, do you or your fact checkers know the amount of $ @CDCgov *receives* from the pharmaceutical industry?
unherd.com/2023/05/robert…

Just published
🇰🇷Korean nationwide study reports 8 cases of "sudden cardiac death (SCD) attributable to VRM [vaccine-related myocarditis] proved by an autopsy"
All developed<1 week post mRNA vax
2 females, 6 males
3 post dose 1, 5 post dose 2
All <46 yo
academic.oup.com/eurheartj/adva… Note these deaths were not limited to males or dose 2.

This was of a total of approximately 23.5 million people vaccinated in the 12-50 age group, but around 28% of vaccinated received non mRNA & no autopsy proven VRM deaths were due to non-mRNA vax

Next week I'm returning to DC to testify before congress about systemic problems within the CDC, their process for developing public health guidelines, errors made & the scientific integrity of MMWR

The goal is to improve US public health

I'm seeking thoughts, ideas & receipts Was 2 months ago I was in DC testifying about school closures in the US. I'm thrilled by the conversations it started

I owe so many of you a thank you for your input in that written and spoken testimony. I honestly believe I looked at everything you sent & posted here on Twitter

Who else is concerned about premature birth risk from new Pfizer RSV vax just recommended by VRBPAC?

Premature births >20% higher in vax arm: 5.7% vs 4.7% p=0.09 (I calculated); underpowered to say if real!

But⬆️also seen w/all 4 formulations (See 2b data right) & GSK RSV vax🧵 Absolutely🤯when Pfizer said all they would have needed to do to determine whether safety signal was real was enroll 5,000 instead of 3,700 in each arm.
What the heck? Why would FDA not make them expand the trial?
(also annoyed this isn't avail to public)
nejm.org/doi/full/10.10…

These 2 lines (🟠&🔵) I think show why the zoster vax-dementia study finding (⬇️es dementia in ♀️ only) is unconvincing & likely spurious

My🟠line shows the age-dependent trend of dementia dxs looks unaltered
My🔵line=what we'd expect if discontinuity were real but we DON'T see

https://twitter.com/PGeldsetzer1/status/1661776682993463297

Thanks to @beenwrekt for pointing out the linear fit for the entire population (men & women) looks better than the regression discontinuity. I wanted to see if this applied to women too and I think it does.

https://twitter.com/beenwrekt/status/1662090133771010048

Agree w/@MartyMakary & maybe now that she's stepping down we can interview @CDCDirector re:

1. Why 3ft of distance was okay for her own kids but she wanted 6ft in schools as CDC director

2. Why @CDCgov didn't alter their vax recs when they learned about post-vax myocarditis
🧵

https://twitter.com/MartyMakary/status/1655294847702519815

3. Why she recommended masking school children based on very obviously flawed observational studies in @CDCMMWR

4. Why she said vaccinated people don't carry the virus

If "masks work" vs covid, why don't the authors cite real life evidence?

They cite N95 particle filtration but can that be equated to infection prevention?

Can people not be infected through their eyes?

Are there not holes on the sides of most masks? scientificamerican.com/article/masks-… Strikes me as UNscientific to start with the assumption masks work rather than ask for good evidence it's true.

They compare masks to life jackets but come on...we can see with our own eyes life jackets keep people afloat.

What is it exactly we can see masks doing?

Today in her congressional testimony @rweingarten mentioned our Wisconsin study in @CDCMMWR multiple times as evidence schools needed "layered mitigation" to reopen
She also mentioned me in her written testimony
This statement👇 & her interpretation of our study are incorrect🧵

https://twitter.com/Rstorechildhood/status/1651285778117296148

I was senior author of this WI study & as we said in our paper, because we had no control group:

"It was not possible to determine the specific roles that mask wearing and other disease mitigation strategies played in the low rate of disease spread"
cdc.gov/mmwr/volumes/7…

🏴󠁧󠁢󠁥󠁮󠁧󠁿New self-controlled case series of 12-29 yos in England w/findings not inconsistent w/@FLSurgeonGen's study, this finding a 70%⬆️d incidence of cardiac death post dose 2 mRNA vaccine in 12-29 yo males, however it wasn't significant (1.70 [0.98, 2.97])🧵
nature.com/articles/s4146… If real, this increased incidence would correspond to 1 additional cardiac registered death for every 360,000 males aged 12-29 who received a second dose of an mRNA vaccine.
This was in the 12 week risk window post vaccination
This signal was not seen in females or after dose 1.

🇳🇴Such an impressive Norwegian study on Post Covid Condition
~50% of both cases & controls had PCC @ 6mos!
And COVID not an independent risk factor!
Symptom severity at baseline main risk factor, whether covid + or -
Ages 12-25
12/24/2020-5/18/2021
None of included controls sero+ Link to study here: jamanetwork.com/journals/jaman…

What's going on here on the Gram?
US academic med centers like @JohnsHopkins just unabashedly putting out adverts for pharma
Is biv booster for those <50 really a pressing PH issue?
(&cited study likely confounded by biv boosted being more likely to test cdc.gov/mmwr/volumes/7…) @JohnsHopkins Of course much of Europe doesn't even recommend the biv booster for this age
But this is nothing new for the US-pushing medical products that make $ w/o good evidence of health benefit
Just one example: the shocking (to me moving from DK in 2015) push to prescribe narcotics