🔥new paper: Sotrovimab restores neutralisation against current Omicron subvariants in patients with blood cancer🔥

Now published @Cancer_Cell

@MaryYiWeiWu @cancerBRC @fendler_annika @stcshepherd @EdjCarr @dremmacbw @TheCrick @royalmarsdenNHS
👇
doi.org/10.1016/j.ccel…
🧵1/9 2/9
People with blood cancer have 🔼 risk of severe COVID-19 as they make 🔽 neutralising Abs after vaccination
Many can’t take antivirals like Paxlovid due to therapy interactions
Therapeutic Abs protected from COVID-19 in pre-Omicron era but what about XBB, XBB.1.5 and BQ.1.1?

📰Out NOW in @CancerCell ‼️👉cell.com/cancer-cell/fu… 🎉What underpins anti-PD-1 response in ccRCC?

Results from ADAPTeR Phase II clinical trial, bulk/single-cell analysis of longitudinal tumour samples ⤵️(1/15) @royalmarsdenNHS @TheCrick @uclcancer Intratumour heterogeneity (ITH) is pervasive in ccRCC & longitudinal data on anti-PD1 response is scarce 🚨 Thus we performed multi-omics analysis on 115 multiregion tumour samples, taken at baseline, week-9, & PD, from 15 treatment-naïve patients treated with nivo 🔬 (2/15)

2nd paper 📰📰 Vaccine Cohort 💉 We analysed vaccine responses in 585 patients with cancer after COVID-19 vaccination, measuring neutralising responses against the original SARS-CoV-2 and variants of concern (incl. Delta) and T cell responses (1/11) After two doses of either Pfizer-BionTech or Oxford-AstraZeneca, 83% of infection-naïve patients with cancer developed antibodies against the original strain, but only 54% of those had neutralising antibodies against Delta (2/11)

1st paper📰 Infection Cohort 👉We analysed neutralising and T cell responses in 118 patients with cancer, where SARS-CoV-2 infection was defined by positive PCR or antibody test. COVID-19 severity ranged from asymptomatic to severe (1/6) nature.com/articles/s4301… Most patient with solid cancer had neutralising antibodies while blood cancer patients had reduced or absent neutralising responses (2/6)

Two papers OUT NOW in @NatureCancer ‼️ What does the immune response in cancer patients look like after COVID-19 vaccination or SARS-CoV-2 infection? We present results from the #CAPTURE study. Two-part thread (vaccine & infection cohort findings) to follow... 🧵🧵 (1/4) About the study: #CAPTURE a prospective, longitudinal cohort study established in April 2020 and conducted at @royalmarsdenNHS and @TheCrick. #CAPTUREstudy recruitment and analyses are ongoing (2/4) cell.com/cell/fulltext/…