CIRS isn't just feeling a bit off from mold exposure.

Biotoxins cause multi-system, multi-symptom dysfunction (especially immune), which can be measured & tracked with certain biomarkers.

Here are the markers most conventional doctors won't test for 👇 MMP-9

Normal: 85-332 ng/ml

Above range =

⚠️Increased blood-brain barrier permeability
⚠️Adverse effects on joints, muscles, and nerves
⚠️Destruction of connective tissues in arthritis, cardiomyopathy, atherosclerosis
⚠️Increased risk of atherosclerotic plaques (increases OxLDL)

Seen a few binary takes on cannabis lately.

Cannabis isn’t all rainbows and lollipops, but it’s not all dribbling brains either.

Get the balance right, and THC/cannabis can be a powerful therapeutic.

A deep dive 🧵on mastering cannabis use When cannabis is abused, there are considerable downsides.

Some of these are highlighted well in this recent thread.

Others are context dependent, and we’ll shed some light on those later.

https://x.com/Outdoctrination/status/1890400273345945936

This thread hits on some good points about the negative effects of Cannabis.

But it mainly focuses on the effects of cannabis abuse.

There's an entirely different (therapeutic) side to cannabis when it's used correctly.

A deep dive 🧵on cannabis 👇

https://x.com/Outdoctrination/status/1890400273345945936

Cannabis can be either a drug of abuse or a powerful therapeutic depending on several factors:

Low vs high dose THC
Therapeutic vs hedonistic use
Risk vs benefit
Type of cannabis
Epigenetic risk factors (susceptibility to psychosis and schizophrenia)

We'll cover them all

On some recent bloods, I had very high levels of serum B12, even though I wasn’t supplementing.

After some research, I found a potential explanation that indicates it may be due to a functional B12 deficiency.

I'll try and explain this paradox..... 🧵 There are different forms of B12 (active, inactive, methylated).

Serum B12 is not a good indicator of functional B12 status, because it cannot tell these forms apart.

High serum B12 could be mostly the inactive form, and not the functional (active) form.

If you suspect issues with mold, it can be overwhelming to know where to start.

Mold illness is financially & logistically demanding. So it helps to save time and $ from the start

For $15, you can be 92-98% certain that mold is an issue worth looking into

🧵on VCS testing👇 The Visual Contrast Sensitivity (VCS) test measures changes in eyesight.

Specifically in the ability to detect contrast between light & dark patterns.

CBN is a 'minor' cannabinoid with some major benefits.

It has potent neuroprotective effects, due to it's role in restoring mitochondrial (dys)function.

Let's dive in 👀 👇 Oxytosis/ferroptosis is a specific cell death pathway that involves mitochondrial dysfunction.

This pathway is involved in neurodegenerative diseases.

It can be triggered by environmental toxicity, iron imbalances, elevated glucose levels, inflammation and oxidative stress.

Mitochondrial dysfunction is often a core-component behind symptoms of #MECFS

Besides environmental pollutants, other major causes of mitochondrial dysfunction include mycotoxins

Could mycotoxins be a major contributor to ME/CFS?

Let's find out 👇 Mycotoxins are toxic metabolites produced by various species of mold.

They can cause a range of health problems, from mild allergic reactions to severe and chronic illnesses.

Endothelial dysfunciton, capillary hypoperfusion & pulmonary hypertension are some major complications in CIRS.

They drive a low oxygen environment leading to symptoms including fatigue, chest pain, PEM and shortness of breath.

Whats driving them + how to fix

🧵👇 TGF-β1, MMP-9 , C4a are immune messengers released in a biotoxin response.

They drive drive fibrosis and tissue remodelling.

The result is a reduced supply of oxygen to tissues (Capillary hypoperfusion).

Here's a detailed overview

t.ly/qAm5l