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Walter W. Chen, MD, PhD Profile picture
Walter W. Chen, MD, PhD
@WalterWChen1
Harvard/MIT MD-PhD + @TheBCRP grad, NICU fellow @UTSWNews, postdoc @RJDLab, @statnews Wunderkind, @the_asci E-Gen awardee, studying organelles, views = mine
May 3, 2024 • 9 tweets • 2 min read
V happy to share my work in @RJDLab @CRI_UTSW from past 2 yr! In equal collab with Tony Rodrigues, @dwendscheck, Jorge Azevedo’s lab, @warscheidlab, we have discovered PEX39, the first human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr! 🧵biorxiv.org/content/10.110… Peroxisomes are metabolic organelles essential for human health. Peroxin defects can cause severe disease as early as neonatal period. PEX7 binds newly made enzymes containing a type 2 peroxisomal targeting signal (PTS2) to enable their import from the cytosol into peroxisomes.