Unlike traditional pharmacological inhibition, targeted protein degradation (TPD) induces ubiquitin-dependent degradation of proteins. However, it’s poorly understood which/why certain proteins are susceptible to TPD. We developed a machine learning model to answer this question. Our paper is now available on #bioRxiv biorxiv.org/content/10.110…. This work couldn’t be accomplished without help from @ssroyburman, Jiaye Chen, @kdonovan1008 and other co-authors. Appreciate the great support and supervision from @XShirleyLiu, @ctokheim and @eric_fischer.