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John Lovell Profile picture
John Lovell
@_johntlovell
Evolutionary biologist and outdoor enthusiast | comparative & quantitative genomics (mostly plants) | HudsonAlpha Genome Sequencing Center & Joint Genome Inst.
May 23, 2022 • 8 tweets • 4 min read
We've been exploring the new #T2T human genome assembly compared to previous versions (our news and views article is out today, link below). Some observations:
(1) Its pretty amazing what the human genome project was able to do in 2004: large-scale gene order is totally conserved (2) Some of the chromosomes are nearly identical between the 2013 GRCh38 assembly and T2T. For example, here is a zoom in on Chr10 - just a few gaps in the pericentromere that were filled in with tandem repeats in T2T.