Full Professor and Intensivist, HIAE Senior Research Fellow at ANZIC-RC Investigator of #PReVENT, #PROBESE, #PROTHOR, #DESIGNATION, #ACTIVE and #RELAx trials
Dec 9, 2020 • 25 tweets • 8 min read
The #RELAx trial has been published today in @JAMA. It was coordinated by Anna Algera. This thread is to explain the rationale, what we did, the findings and the meaning.
The rationale of #RELAx is based on the following premises.
jamanetwork.com/journals/jama/…
First, there is NO adequate evidence on the level of PEEP in non-ARDS patients. Most of the studies are old, conducted in post-surgical patients (short-term ventilation), and were not powered to detect differences in patient-centered outcomes.
