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Aaron Ring Profile picture
Aaron Ring
@aaronmring
Associate Professor at @FredHutch Studying #cytokines, (auto)antibodies, and #cancerimmunotherapy Founder: @SimchaTx, @Seranova, & Stipple Bio
Mar 9, 2023 • 8 tweets • 3 min read
How does primary SARS-CoV-2 infection compare to mRNA vaccination when it comes to autoantibody development? @_BlueJay3 led an effort with @VirusesImmunity and her lab and our @BRIseattle collaborators to answer this question: nature.com/articles/s4146… We and others previously found that SARS-CoV-2 infection is associated with the development of new autoantibodies (AAbs), with a trend towards increasing AAb levels with more severe infection. nature.com/articles/s4158…
Sep 12, 2021 • 9 tweets • 2 min read
With PhD and MD/PhD admissions season kicking into gear, I have deeply mixed feelings about recruiting the next generation of trainees into the biosciences. Many do not realize that the biotech industry is in grave danger with vast swathes of research jobs in jeopardy. Bills like HR3 and similar provisions in the proposed $3.5T spending bill would absolutely devastate the biopharma industry. If passed, companies will have to dramatically cut R&D activities. This blow will predominantly hit scientists, with some estimating >200,000 jobs lost.
Jun 24, 2020 • 18 tweets • 8 min read
Our lab's first paper (rdcu.be/b49xK) is now out at @nature. We found that the cytokine IL-18 can drive potent anti-tumor activity from the innate and adaptive immune system, but that its activity is restricted by a high-affinity "decoy receptor" IL-18BP. (1/) Cytokines were the first modern drugs that unambiguously proved the immune system could be a powerful target against cancer. IL-2 had an ORR of ~15% in metastatic melanoma and renal cell carcinoma, with 6% of patients having complete, durable responses that lasted decades. (2/)
Mar 28, 2020 • 4 tweets • 1 min read
Exchange between @VirusesImmunity and @jbloom_lab raises an emerging paradox in COVID-19. Neutralizing Abs are the long term solution to prevent disease, but there is concerning evidence that anti-SARS-CoV-2 antibodies may contribute to lethal immunopathology. (1/4) Serological studies so far show that patients with severe COVID19 have the highest titers of anti-viral IgG. Akiko also highlighted a preclinical NHP study implicating pathological macrophage activation by anti-SARS-CoV-1 spike Abs. (2/4)