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Alexander Hoischen Profile picture
Alexander Hoischen
@ahoischen
Genomic technologies: WES/WGS, longreads, somatic mutations; Immuno-genomics: rare diseases; immunodeficiencies; inborn errors of immunity; clonal hematopoiesis
Jul 24, 2020 • 14 tweets • 4 min read
1/7
 TLR7 loss-of-functions mutations can lead to an immunodeficiency with a strong predisposition to develop a severe form of COVID-19 in young male patients. jamanetwork.com/journals/jama/… 2/7 As such, this is the first description of a monogenic risk factor related to COVID-19 and a first risk factor next to the known general risk factors (age, male sex, cardiovascular disease, chronic disease, obesity).