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Alan Tomusiak Profile picture
Alan Tomusiak
@alantomusiak
building something new to prevent cancer
Jun 12 • 8 tweets • 3 min read
Absolutely crazy month for progress in the world of genome instability & DNA repair, especially as pertaining to aging. A few of the most exciting papers, a 🧵: Image Above review just released by @schumacherbj (+@ArBujarrabal, @George_Garinis) on boosting DNA repair (). Very useful table embedded listing many, many compounds that improve DNA repair or kill defective cells. nature.com/articles/s4157…Image
May 7 • 8 tweets • 3 min read
Just posted a piece I've wanted to write for a long time.

Maximum Lifespan vs. Healthspan (or - why you cannot diet your way to live to 140), a 🧵

Take a look at these two mice, from the famous Baker et al. 2016 Nature paper:Image One (on the bottom) has had all of its senescent cells cleared. It is healthier across the board. As you could imagine, the average lifespan of these mice is longer than ordinary mice.

But the longest-lived mouse in this group does not live much longer than the wild type. Image