Allison Fitzgerald, MD, PhD Profile picture
Heme/Onc Fellow @DanaFarber/@MassGeneralBrigham. Former @BrighamMedRes and @Georgetown MD/PhD. Passionate about true crime podcasts, reality TV, and Taco Bell.
May 31 7 tweets 2 min read
With all the excitement around daraxonrasib, I needed to refresh my RAS inhibitor knowledge, so here we go: KRAS is a GTPase that toggles between and GDP-bound OFF state and GTP-bound ON state. In healthy cells RAS becomes transiently activated in response to extracellular growth signals and starts downstream signaling. Image