Glad to see vaccine supporters raise awareness of the inadequacies of vaccine compensation schemes

We wont reduce vaccine hesitancy if those who are injured get abandoned

https://twitter.com/Michigan_Noah/status/1705956083385127029

My (UK) experience here 👇🏻


UK petition for change here:

In the UK, even some VITT cases have been rejected for not being causally related to the vaccine. Y'no, VITT, the condition unique to covid viral vector vaccines 🤷🏻‍♀️

https://twitter.com/angryhacademic/status/1668669584839258129

petition.parliament.uk/petitions/6379…

Ive just learnt about post thrombotic syndrome (PTS).

Heres an idea:

Covid/vaccine --> clots --> damaged valves --> venous disease (e.g. iliac vein compression)

#longcovid #postvac #teamclots Add inflammation ± predisposition to connective tissue weakening, could a sort of PTS (not necessarily from classic DVT, and more on a micro scale) be the link between covid/spike and iliac vein compression etc that folks like @jfvaughnmd09 are seeing? 🤔

Checked my post and to my surprise ive been offered flu and COVID vaccines

To my knowledge, i dont meet any of the criteria - have they realised COVID is a thrombotic vasculitis??

Even ignoring my vaccine injury, vaccines are contraindicated when taking fludrocortisone

Very frustrating to see side effects being reduced to acute side effects and "very rare" and "quick to recover from" myopericarditis. This is upsetting for 2 reasons:
1. They emphasise men (which is what the data show) but women i know with myoperi were dismissed

This is an interesting paper. Some highlights 🧵


n = 20 mRNA vaccinated participants (+ unvaccinated controls + COVID positive controls) looking at spike protein fragments ("PP") in biological samples onlinelibrary.wiley.com/doi/10.1002/pr…

https://twitter.com/DeansKevin/status/1697725393619324949

PP-spike detected in 50 % of biological samples analysed

The presence of PP-spike was independent of spike antibodies

PP-spike detected up to 187 days post-vaccination

Antihistamines


4 histamine receptors which have different actions: H1, H2, H3, H4

Note that over the counter antihistamines target H1. Famotidine and similar (often used for stomach protection) targets H2
🧵sciencedirect.com/science/articl… All histamine receptors are GPCRs - a hot topic in #longcovid!

H1 mainly implicated in immediate hypersensitive reactions - wheezing, itching, coughing, blood pressure drop

H2 mainly affects gastric mucosa, vascular smooth muscle, brain, fat cells, basophils, neutrophils, etc

JAMA recently published about misinformation spreading physicians on social media. I doubt these were the kind of tweets they were targeting.

This kind of misinformation imo is at least as, if not more, dangerous

https://twitter.com/Bob_Wachter/status/1692591127826661845

I think this because it:
• is from someone in a position of influence and power

• sounds very reasonable and logical

• can loosely be traced back to some evidence somewhere with a particular interpretation (element of truth, like much misinfo)

Disseminated intravascular coagulation (DIC)


Excessive generation & dissemination of coagulation → production & deposition of small/mid-size fibrin clots → alters microcirculation → ischaemic necrosis

sound familiar?🤔
#longcovid #postvac #teamclotsncbi.nlm.nih.gov/pmc/articles/P… ischaemic necrosis occurs in many organs, especially the kidneys and lungs

🤔lots of long COVID/post vac patients have new onset kidney problems.
🤔i've never had an answer as to what the matched defects were in my V/Q lung scan

The VDPS @NHSBSA @MHRAgovuk largely based their assessment of causality WRT #vaccineinjuries on population based signals.

This is 1 (limited) method of causality and precludes n-of-1 causality assessments 🧵

Essential reading: ncbi.nlm.nih.gov/books/NBK19001… Population signals tell us population risk.

If the prevalance of Y is similar after X compared to those who didnt have X, then we can say that those receiving X have no greater risk of Y than if they dont receive X

A problem me (& some of my clients) have with the way medicine works is that drugs are, in some situations, tried sequentially rather than targeted to pathophysiology.

An example of when this problem arises is #POTS 🧵

#medtwitter #neisvoid Theres lots of treatments for POTS (see here: ) and often doctors will just go through them until they find one that works

(The drs that care and understand, that is)lc-sc.co.uk/diagnoses/f/po…

Just went on @BBCRadioScot to discuss the removal of masks in #healthcare

These were my key points:
🧵 1. #SARSCoV2 is still a significant threat to health, increasing the risk of outcomes like stroke and clotting (etc), as well as #longcovid including #longcovidkids

Long covid can be highly disabling and there is no cure

Hey @JohnSpeakman4 I finally got round to reading your (excellent) paper on water turnover


I particularly like that it challenges the un-evidenced "drink 2 L/d" malarkey...using evidence!

But I note you perpetuate another #hydration myth in there...🧵science.org/doi/10.1126/sc… "Despite adaptations to minimize dehydration, humans can survive for only ~3 days without consuming water"
Firstly, your team cite Popkin et al who write "Without water, humans can survive only for days"

They didnt mention "~3 days"
But more importantly...ncbi.nlm.nih.gov/pmc/articles/P…

just reading this now and it's worth emphasising how many pleiotropic effects statins have:
antioxidant
anti-inflammatory
antithrombotic
reduction of angiogenesis
improvement of endothelial function
reduction in the levels of blood uric acid
inhibition of platelets aggregation

https://twitter.com/dr_todd/status/1671861216170393600

the review discusses fibronectin, a recently exciting thing in the long covid space

it's involved in atherogenesis, so it's reduction can reduce plaques

fibronectin can also stimulate mast cells 😮

A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors


#MECFS #LongCovid #postvac #teamclotssciencedirect.com/science/articl… Lots of interesting links in here:
Muscarinic M3 receptor dysfunction → endothelial dysfunction → blood flow problems

Role of prostaglandins in vasodilation (think #MCAS)

Ischaemia (think #microclots) causing prostaglandin release

It is with both excitement and trepidation that I announce I have started my own business: Long Covid Scientific Consultancy.

Please check out the website here 👉🏻

And share with any friends / family who are lost on their own #LongCovid or similar journey https://t.co/ToJX0i39Mg https://t.co/c4ElBCZn8Flc-sc.co.uk

https://twitter.com/angryhacademic/status/1659286684603674632

Many patients ask me for advice about #LongCovid / similar #postvac injuries, but with my own declining health it has become harder to keep up especially whilst trying to hold down a job. I'm hoping therefore this is a way to give patients the time & attention they need & deserve

I think so much in life there's a System and once there's a System us peoplebots follow that System and cannot deviate. Because theres a System no one takes accountability. The System speaks the only truth. The System is its own being. No one can overrule the System. No one is accountable to the System and the System is accountable to no one. The System is the system and only the System can change the system. But since the System is not real, the system cannot change.

The #VDPS send me their decision today.

They accept causality to the vaccine on the following grounds:
My acute flu-like side effects
Tinnitus

Therefore they consider me 1-5 % disabled from the vaccine, and ineligible for payment

#vaccineinjuries #postvac The document is very long and i need to re read to check ive interpreted correctly. Currently im quite in shock. The vaccine has ruined my life. Based on others, i expected rejection but how theyve determined < 5 % disabled is beyond me

Head-down bed rest impairs vagal baroreflex responses and provokes orthostatic hypotension
journals.physiology.org/doi/abs/10.115…

30 days head down tilt (HDT) caused 4 of 10 healthy participants to faint after standing up for 5 minutes. some interesting stuff going on... Heart rate:
Those who did faint, had a much smaller increase in heart rate on standing, just 23 ± 5 bpm, compared to non-fainters 49 ± 10 bpm

This suggests high heart rate is protective of fainting (in these very peculiar conditions)

Cardiovascular Deconditioning (20 Hours Bedrest with -5° Head-Down Tilt (HDT)) in Middle-Aged Healthy Men
sci-hub.se/10.1016/0002-9…
authors suggest during HDT MAIN cause of deconditioning is "an altered distribution of body fluids & intravascular pressures" & shift of fluid to head this is potentially VERY important for #POTS: it suggests that our dysregulated body water regulation can be a primary source of deconditioning-like cardiovascular issues.

this means: fix the haemostasis problems to improve cardiovascular condition

#MedTwitter

Folks who support the @GoodLawProject GMC case want to reduce vaccine hesitancy.

Policing what they deem misinformation and making the @gmcuk arbiters of truth will not achieve that What will reduce vaccine hesitancy?

One thing would be to acknowledge, support, and be curious about #vaccineinjuries

I think it would do more to reduce vaccine hesitancy if the money raised went to supporting the vaccine injured.

Why?

If you have a trial for a heterogeneous condition like #MECFS, then looking at average effects is no longer a good option to determine effectiveness.

If half improve and half get worse, we determine the intervention ineffective.

#academict Instead we should explore *why* those who responded did respond and vice versa.

For the non responders we should then move them on to another intervention

We also need to consider poly-interventions to address multiple pathologies

the autonomic nervous system has a branch that does not use acetylcholine or noradrenaline as transmitters. instead it uses other things, like nitric oxide, ATP, serotonin, neuropeptide-Y, etc
link.springer.com/content/pdf/10…

some thoughts RE #MECFS #LongCovid #teamclots #dysautonomia 🧵 Nitric oxide gets released (depleted?) in ischaemia reperfusion injuries
jnnp.bmj.com/content/67/1/1

Dysmetabolism is commonly reported in #MECFS
ncbi.nlm.nih.gov/pmc/articles/P…

(Circulating) Serotonin may get depleted with platelet activation
portlandpress.com/biochemj/artic…