Evolutionary, statistical and population genetics at UT Austin.
May 8, 2022 • 25 tweets • 8 min read
In work led by Carrie Zhu, we consider some puzzles that arise in evaluating autosomal gene-by-sex interaction (GxSex) in complex human traits.
We argue that polygenic GxSex may be pervasive but largely missed by current approaches.
biorxiv.org/content/10.110…
1/n
Should we polygenic effects to depend on context? In other organisms, where the environment can be controlled / manipulated, we know gene-by-environment interaction is the rule, not the exception. 2/n
Nov 2, 2021 • 8 tweets • 2 min read
Thanks for the considered response @LB_Barreiro. To clarify, I wasn’t commenting on how we go about studying *variation* in human traits; as a population geneticist I obviously agree that there is lots of important biology to be learned from studying heritable variation. 1/8
Having said that (a), we learned how the interferon response works mostly from mice, right?
2/8
Nov 1, 2021 • 18 tweets • 3 min read
Have been discussing with @molly_przew when it makes sense to organize studies in human genetics around ancestry, and when it seems to us less well justified and fraught. 1/18
I expect most of us would agree that it would be much fairer, and fruitful, for genomics to extend beyond the usual scientists, participants, and topics. 2/18
