Arjun (Raj) Manrai Profile picture
Assistant Professor of Biomedical Informatics, Harvard Medical School @HarvardDBMI | Founding Deputy Editor, @NEJM_AI | Co-host, NEJM AI Grand Rounds
Apr 10, 2019 9 tweets 5 min read
(Thread) 2019 problem: you have a big dataset and everything is significant after Bonferroni. What's spurious; what's real? How do you prioritize? Happy to share my take w/ John Ioannidis & @chiragjp out now in the American Journal of Epidemiology: academic.oup.com/aje/advance-ar…

1/n 👇 Some background: Inspired by Genome Wide Association Studies (GWASs), 'X-WASs' have emerged as systematic, agnostic, and reproducible approaches to discovery with non-genetic data (e.g. X = Environment, Medication, Phenotypes...etc.) For ex., the EWAS by @chiragjp et al. 2/n