Graduate student studying how cells move through living tissues. š microscopy, image analysis, cell biology and science outreach. https://t.co/j864L5gzLu
May 23, 2022 ā¢ 18 tweets ā¢ 8 min read
What is going on with these zebrafish basal skin cells? I invite you to a š§µ on wound healing, hydraulic fracking, and macropinocytosis, from subcellular to tissue-scale! All part of my favorite PhD project, now up on bioRxiv (1/17)
biorxiv.org/content/10.110ā¦
This was a fantastic collaboration with co-first author @SatheMugdha (dextran and endosome obsessed), along with @EllenLabuz and Chris Prinz (professional fish stabbers). Being part of the Theriot lab zebrafish crew was such a joy! (2/17)
Main question: how do skin cells know when (and where) injury has occurred nearby?
A š§µ about how #zebrafish embryos sense wounds via osmotic AND electric cues, with plenty of cool movies! (1/12)
biorxiv.org/content/10.110ā¦
š¦š skin cells respond to wounds FAST: within seconds after injury, cells 100s of microns away start reacting. How do they know so quickly?
(Most movies in this š§µ are of LifeAct-GFP in the basal cell layer of the embryonic tailfin, reacting to a wound to the right.) (2/12)