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Vijay Sankaran Profile picture
Vijay Sankaran
@bloodgenes
Pediatric Hematologist/Oncologist, Geneticist, Stem Cell Biologist - @DFBC_PedCare, @BostonChildrens, @DanaFarber & @broadinstitute
Jan 25, 2022 • 16 tweets • 11 min read
Are you interested in how we can learn more human biology by integrating #singlecell genomics and #GWAS?

Please check out our preprint:
#V2F mapping at single-cell resolution through network propagation

biorxiv.org/content/10.110…

Led by @fulong_yu! A short 🧵 (1/n) #GWAS have identified innumerable variants associated with disease, as shown in this recent @GWASCatalog plot, yet our understanding of the function of most variants is lacking. #V2F (2/n)
Aug 17, 2021 • 15 tweets • 7 min read
Wonderful to have our work on using genome editing in single cells to better understand hemoglobin switching published in @NatureComms today. Terrific work by Yong Shen, @JeffreyVerboon, and colleagues from the @JianXuLab and Orkin labs: go.nature.com/3k3OanG
👇Short thread 13 years ago, we had identified BCL11A as a key regulator of fetal hemoglobin (HbF) expression: science.sciencemag.org/content/322/59…

But how was it acting to silence HbF? (1/n)