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First up, the Industry/business briefing
Lewis Goldberg opens the briefing, noting the hard work that has preceded today and that we're on the brink of psychedelic-assisted therapies becoming available
May 11, 2023 • 9 tweets • 2 min read
𝗣𝘀𝘆𝗰𝗵𝗲𝗱𝗲𝗹𝗶𝗰𝘀 & 𝗙𝗶𝗯𝗿𝗼𝗺𝘆𝗮𝗹𝗴𝗶𝗮
🌍Fibromyalgia (FM) affect 210 million people
❤️🩹Current treatments don't work well
🏥 Three trials have started
🧵 Psychedelics for FM blossomanalysis.com/topic/fibromya…
FM is a complex and misunderstood medical condition characterized by chronic widespread pain, fatigue, sleep disturbances, and cognitive symptoms
The exact cause of FM remains unknown, but it is believed to involve a combination of genetic and environmental factors
Nov 8, 2022 • 7 tweets • 2 min read
Ketanserin can stop trip effects 🛑 after a psychedelic is already ingested
It was known that taking ketanserin before could prevent a trip, now it is shown to rapidly stop an ongoing trip
doi.org/10.1093/ijnp/p… 1/7
Anna Becker & co from the Liechti Lab (in collaboration w/ @mindmedco) gave 24 participants 100µg LSD followed by 40mg ketanserin 1 hour later
At the 3.5-hour mark, the subjective effects were gone (instead of 8.5 hours, a 60% reduction)
But what is even ketanserin? 2/7
Oct 27, 2022 • 9 tweets • 3 min read
How do psychedelics work in the brain?
This & more in the latest update on the latest psychedelic research 🧵 1/9
.@kwanalexc et al review the neuroscience of psychedelics
It covers the chemistry, receptors and molecular signalling of psychedelics, as well as recent insights into how psychedelics modulate neurons and neural circuits
Research by Frederick Barrett et al. finds that LSD enhances music-evoked emotions
I.e. the same music, whilst under the influence, evoked a stronger emotional reaction 2/8
Feb 1, 2022 • 7 tweets • 2 min read
Last month in Psychedelic Research
🍄 Largest published trial with psilocybin to date
💉 Positives for ketamine and alcoholism but not PTSD
📸 Flashbacks in clinical research with LSD
🧵 & 📃 1/6 Psychedelic Research January 2022 blossomanalysis.com/psychedelic-re…
Psychedelic research hit the ground running at the turn of the new year
@jamesrucker et al. found that psilocybin can be administered safely in up to 6 people simultaneously in the largest published trial with psilocybin 2/6
Jan 31, 2022 • 8 tweets • 2 min read
Psychedelics: A Solution to a Global Mental Health Crisis? Not likely.
Psychedelics are poised to be a paradigm shift in mental healthcare, but will this shift have a global impact?
We discuss some reasons why this may not be the case
@JacobSAday & co tackle them in a recent pre-print
Some of the issues:
1) Difficulty masking, participants know if they have gotten a high-dose
2) Positive media of clinical benefits influences expectations
2/8
Dec 3, 2021 • 277 tweets • >60 min read
Live from @HorizonsConf we will be reporting on the talks today 'Focus on Clinical Research' 1/many
Anthony Bossis kicked off the day with some moving words
"We're at our best when seeking"
"We're at our best when we collaborate to try to heal one another. And to heal this very fragile planet"
It accounts for 7.5% of all years lived with a disability (YLDs)
Making it more than twice the burden of anxiety
How can psychedelics help? 2/14
Nov 3, 2021 • 9 tweets • 4 min read
𝗣𝘀𝗶𝗹𝗼𝗰𝘆𝗯𝗶𝗻 𝘅 𝗗𝗲𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻
As everyone is eagerly awaiting @COMPASSPathway's Phase IIb trials, we recapped studies that looked at depression & psilocybin
We were surprised that the total number of participants was only 195
blossomanalysis.com/key-psilocybin… 1/8
This pales in comparison to the 233 participants in the COMP360 trial, or to many of the (much more easily available) ketamine trials
Noted should be that of the 195 participants. 151 were part of randomized-controlled trials (RCTs) and only 44 in open-label trials
Why so? 2/8
Nov 2, 2021 • 11 tweets • 3 min read
Last month in 𝗣𝘀𝘆𝗰𝗵𝗲𝗱𝗲𝗹𝗶𝗰 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵
💊 Microdosing LSD leads to resynchronization patterns
😫 How psychedelics can help with chronic pain
👩🏫 Parents approve of ketamine use