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Brahmajee Nallamothu Profile picture
Brahmajee Nallamothu
@bnallamo
Cardiologist, health services researcher, editor, second luckiest man alive...
Jul 9, 2022 • 4 tweets • 3 min read
Why do we need a "0 mg" atorvastatin tab?

To find out start by reading this elegant n-of-1 trial by @TudorKate - one of my favorite @CircOutcomes articles this year...

ahajournals.org/doi/10.1161/CI…

1/ n-of-1 trials study how to optimally individualize treatments like statins. But they are hard to implement in routine practice. This study overcomes one barrier by introducing an "unblinded arm" (discussed in a great tweetorial by @Ricky_Turgeon)...



2/
Sep 14, 2021 • 6 tweets • 3 min read
“Nullius in verba.”Take no one’s word for it. A cornerstone of science for 350 years.

1/ Except that we often do have to take authors’ words for it. Most methods sections are skeletons of what is actually done - especially in computationally heavy studies.

2/
May 1, 2021 • 15 tweets • 6 min read
De jure segregation within US hospitals ended in the 1960s.

But does de facto segregation still exist? And if it does, is it related to outcomes?

Questions posed in a paper led by @dorkstweet with @AkbarWaljee @ekownyankah.

1/ Image Extensive prior work has shown outcome differences between Black & White patients after surgery due to patient & hospital factors. In this paper, for example, Black patients undergoing CABG were sicker & more often treated at low-volume hospitals.

2/
ahajournals.org/doi/full/10.11…