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Brett Heimlich Profile picture
Brett Heimlich
@brettheimlich
Cardiovascular Medicine Fellow, and @VUMC_MedPSTP at @VUMC_Heart. Post doc in @AlexBickMDPhD lab. Former @VUMCMedicineres and @NIH_Fogarty fellow.
Dec 6, 2022 • 11 tweets • 7 min read
Hey #CHIP folks, ever wondered how clonal cells in the periphery differ from their wildtype counterparts? check out👉biorxiv.org/content/10.110… @AlexBickMDPhD @FerrellLabVUMC @alyssa_c_parker @PBdoingscience CHIP patient blood is a mixture of normal and mutated cells. Genotyping mutations (@AnnaEnim @landau_lab) is difficult in peripheral blood because DNMT3A and TET2 are not well expressed.