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Brian Liau Profile picture
Brian Liau
@brian_b_liau
Chemical biologist broadly defined. Associate Prof @ Harvard Chemistry and Chemical Biology.
Dec 27, 2021 • 4 tweets • 3 min read
(1/4) Molecular glue degraders are captivating drug discovery, but how might drug resistance emerge? Read our new preprint! We identify themes of degrader resistance involving neosubstrates. #TPD biorxiv.org/content/10.110… (2/4) Using CRISPR-suppressor scanning, we surveyed the resistance landscape across 2 neosubstrates. As expected, the ternary complex interface is a resistance hotspot. But different interfaces can tolerate different amounts of mutations, influencing resistance.