Medical Director Baszucki Group, Host Metabolic Mind podcast. Low Carb Cardiologist. Connecting metabolic, mental, & cardiac health. Views are my own.
Apr 9 • 7 tweets • 2 min read
Your veins and arteries carry the same blood. Same LDL. Same ApoB. Same everything. Yet veins almost never get plaque. Arteries constantly do.
Maybe you've seen the recent discussions about this. It's an interesting question that provides clues in cardiovascular science, and could challenge how we think about LDL and ApoB. 🧵
If ApoB-containing lipoproteins were "sufficient" to cause the disease, we should see plaque everywhere.
But we don't.
We only see it in the high-pressure, high-turbulence environment of the arterial system.
The real "experiment" happens during bypass surgery (CABG).
When a surgeon takes a pristine vein and grafts it into the arterial circulation, something changes.
Subjected to arterial pressure, that vein suddenly becomes susceptible to atherosclerosis.
Nov 6, 2022 • 10 tweets • 2 min read
Lowering TGs with pemafibrate doesnt lower CV events. Does that mean we can ignore TGs? No! A brief thread nejm.org/doi/full/10.10…
Changing a lab value with a drug has NOTHING to do with changing it with a lifestyle approach Just look at HDL and CETP inhibitors.
Jun 29, 2020 • 4 tweets • 1 min read
1/ As medical director at @DietDoctor, it's my responsibility to ensure our material is accurate and trustworthy according to the latest science. Our veg oil guide has received a lot of attention lately, so I want to make sure we have objectively relayed the evidence
2/ So we will have one of our experts on our medical review board thoroughly review the guide to help us in our mission of being objective and helpful with our information. I appreciate those of you who provided constructive feedback to our guide.
