Projecting single-cell transcriptomics data onto a reference T cell atlas to interpret immune responses biorxiv.org/content/10.110… Definition of robust, biologically relevant cell clusters or states by scRNA-seq analysis is typically an iterative, time-consuming process that requires advanced bioinformatics and biological domain expertise

Sharing our preprint on single-cell RNA-seq analysis of tumor-infiltrating CD8 lymphocytes in B16 murine melanoma tumors biorxiv.org/content/10.110… We defined a transcriptomic map of CD8 TIL states, with unbiased identification of terminally exhausted (PD-1+ Tcf1-), memory-like / progenitor exhausted (PD-1+ Tcf1+), naïve and effector memory-like (EM-like) states, including clonality and tumor-specificity information