I write about inflammatory bowel disease providing inspiration, education and deep community. I am Professor of Gastroenterology and UKRIFLF. I also run a lot.
Dec 28, 2022 • 20 tweets • 22 min read
IBD and COVID - a personal recap 🧵
The papers published in chronological order
Guidelines for clinical teams and patients, risk of severe covid, immune response to infection and vaccines - from wild-type virus to Omicron
It is all covered here 👇
Most of this is thanks to the tireless work of @clarityibd and @VIPStudy1 teams
With thanks to all the investigators across the UK
And to the thousands of patients who contributed 🙏
Dec 27, 2022 • 14 tweets • 13 min read
Top 12 papers on gut inflammation from 2022
These are the scientific / translational papers that had the biggest impact on me this year
10 important randomised clinical trials in IBD published in 2022
Thread featuring:
• UPA for UC
• RISA for CD
• ABX464 in UC
• Filgotinib for UC
• Ozanimod for UC
• ADA vs USTE in CD
• FMT plus AID for UC
• High-dose ADA in IBD
SEAVUE: adalimumab and ustekinumab equally effective in bionaive Crohn's disease
Important data for now - ADA considerably more cost-effective
Important data for the near future - USTE biosimilars from q1 2024
🧵 covering:
• therapeutic targets
• treatment strategies
• therapeutic ceiling
• early effective therapies in Crohn's
• the pros and cons of anti-TNF
• new small molecules for UC @ACPGBI@eicc Therapeutic targets in IBD