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bryan dickinson Profile picture
bryan dickinson
@chembioBryan
chemical/synthetic biologist, Luddite trying find better ways to make molecules that do important stuff, dad, @uchicago professor of chemistry
Nov 12, 2024 • 7 tweets • 2 min read
I am very skeptical of the AI/ML/computational methods to predict protein-protein interactions. Prove me wrong.

I present a challenge for anyone who claims they can predict protein-protein interactions.

1/n We are gearing up to post a big paper on de novo protein binder discovery. As part of that we generated lots of data on both novel binders (mini protein scaffolds) and non-binders. For example... 2/n