Roughly one year ago we started out venturing in the world of #proteindesign. Today I am very happy to share our first preprint ‘Efficient and scaleable de-novo protein design using a relaxed sequence space’ (biorxiv.org/content/10.110…) with @sokrypton & @hendrik_dietz 1/x Here we propose and experimentally verify a new way to design protein backbones. We use a relaxed sequence representation allowing the free following of gradients during hallucination. This enables a very efficient search for backbones that minimize the loss function. 2/x