@Kevin_McKernan @SethSHowes Yeah, methylation status is a huge boon with good quality nanopore reads. Darado SUP + methylation analysis would be interesting. Means of deriving useful info, of course, are more contrived for methylation. @Kevin_McKernan @SethSHowes So Dorado is a standard base calling algorithm made by ONT, which has different quality modes, with SUP (super-accurate basecalling) being one of the better algos. It's all ML, the instrument generates skwiggles of electrical signal that need AI to deconvolute