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Chris Wincup Profile picture
Chris Wincup
@chriswincup
Rheumatologist specialising in #lupus & #vasculitis @ King’s College Hospital 🏥 @VersusArthritis Research Fellow @UCL 🧪 OMERACT & EULAR SLE Working Group 🧬
Jul 28, 2023 • 13 tweets • 4 min read
Really pleased to share our recent publication in @RheumJnl

When I first saw our findings I was totally shocked by the higher than anticipated prevalence of neurological and mental health symptoms reported by patients with rheumatological diagnoses

https://t.co/P94izSm0Rtacademic.oup.com/rheumatology/a…
Image We asked patients with rheumatic diseases to report on a wide array of symptoms (n=1853). We also compared with healthy controls (n=463)

Strikingly we found very high rates of cognitive dysfunction (70%) & disorientation (37%)

More than half reported very low mood and anxiety Image
Dec 3, 2022 • 16 tweets • 14 min read
🧵 Short summary thread on our recent publication looking at the impact of Anti-Rituximab Antibodies in #SLE with our recent manuscript published in @RheumJnl

This has been a story that we have been looking at for a few years now

💻 Link - academic.oup.com/rheumatology/a… In spite of failing to meet primary endpoints in the LUNAR and EXPLORER trials, a number of Open Label studies have shown benefit of B cell depletion with Rituximab in #lupus

In England, we have access to the drug for severe and refractory cases 💊 💉

england.nhs.uk/wp-content/upl…