Liv Profile picture
Liv
Jewish (free Palestine), #Disabled, #chronicallyill, lefter than leftist, and unfortunately a #poet. WEAR AN N95.
Dec 4, 2022 20 tweets 5 min read
1st, what a sloppy claim. The hypothesis that intracellular folate deficiency can cause symptomatic elements of #EDS is not new, but I think it's wrong. The #MTHFR polymorphism is SO common and we've gone down the MTHFR rabbit hole before. /1 You hypothesis is that decreased activation of decorin causes structural differences in collagen making it loose enough to cause hypermobility. I find it interesting that other, peer-reviewed studies say that "decorin promot[es] inflammatory activity" science.org/doi/abs/10.112… /2