Okay, here are my prime editing takes. I'm mostly going to try to be a voice of reason here. Not because I'm hyper critical of the paper but because it's necessary. This field is full of mega hype and cool tech, but cool doesn't get us anywhere unless it works as advertised. Overall, I think the work is great. The paper is very rigorous (lots of sites, multiple cell types, and good controls). It certainly deserves recognition because it's a nice approach that's well-executed. That being said, everyone needs to pump the brakes a bit.