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Nutrition, pharmacology, biochemistry, herbalism, and sunlight ☀️🌿 For business inquiries:
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Jul 4 4 tweets 1 min read
All antioxidants chelate free iron and copper, generally iron is the more well studied of the two

Search pubmed for any common antioxidant compound/herb and iron binding/chelation and you'll usually find relevant studies I suspect IP6 is especially potent since it loses its solubility after binding to these minerals

IP6 supplements are pre-chelated (usually to calcium, potassium, and magnesium) but enough of the IP6 seems to be liberated to still have some effect
Jul 3 4 tweets 1 min read
In healthy amounts estrogen is serotonergic and in women is followed closely by progesterone which converts into GABAergic neurosteroids downstream

A large part of the reason why women experience worse mental during menstruation or menopause is the drop in these hormones The higher demand for magnesium and other nutrients during menstruation adds fuel to the fire on top of this loss of inhibitory neurochemistry from the drop in serotonin and GABA
May 26 4 tweets 1 min read
Bioavailability issues with nutrients can be a serious issue

For example: only about 35% of magnesium from food can be absorbed, making it difficult for those with magnesium deficiency to replenish from food sources alone This is one of the benefits of topical magnesium

While it's currently under-researched, topical magnesium can bypass the limits of oral absorption, and seems to be safe even at very high doses such as the amounts used in sensory deprivation tanks
May 24 8 tweets 2 min read
Psychedelics upregulate a number of gene transcription factors associated with some aspects of neuroplasticity and the expression of neurotrophic factors including c-fos, egr1, and egr2

This pathway may be responsible for longterm neurotransmitter alterations psychedelics create Overstimulation of the nervous system by excess dopamine and calcium/glutamate leads to accumilation of fosB, which repressed c-fos creating many of the negative effects seen in addiction and trauma

Upregulation of c-fos clears fosB directly counteracting addiction
May 18 5 tweets 2 min read
If I could only follow 3 accounts on twitter they would be:

@Grimhood @LandsharkRides is a scholar and a gentleman with a fantastic thought process and some of the most abstract, interesting, and poetic insights out there

One of the most underrated accounts on this website by far
Mar 25 4 tweets 2 min read
Interesting thread, but this is misleading

There's a difference between the "fibrous" portion of the root, and actual dietary fiber

Fiber is a term for complex carbohydrates that survive early digestion, you can spit out some of the root and still get plenty of soluble fiber If you actually read the studies on Hadza fiber consumption they actually state flat-out that the high fiber intake is almost entirely soluble fiber dissolved in saliva from chewing roots throughout the day

Fiber intake also varies seasonally and is high in women than men ImageImage
Feb 21 4 tweets 1 min read
Quantum energy levels of glutamate modulate neural biophotonic signals… Spatiotemporal Imaging of Glutamate-Induced Biophotonic Activities and Transmission in Neural Circuits…
Feb 20 33 tweets 8 min read
Tying up loose ends in my understanding of heart disease

Over the past year or so I've written quite a bit on heart disease, in this thread I'll be expanding on its underlying mechanisms, and distilling everything I've learned on how various factors interact

THREAD // Over the years heart disease research has evolved significantly

Initially very simple markers like total blood cholesterol were used to evaluate risk, and many have since been found not to correlate that well and have since been replaced with more specific metrics
Feb 19 4 tweets 1 min read
Most people don't realize that fiber isn't part of a separate class of molecules compared to protein, fat, and carbs

Fiber is anything you can't digest and absorb, most types of fiber are actually polysaccharides, a long complex chain of sugar atoms The difference with fiber polysaccharides vs. other types of complex carbs is that we can't digest fiber in the stomach and small intestine

When they reach our colon they do still feed our microbiome though, so some may be broken there before excretion
Feb 16 4 tweets 2 min read
Fun fact: blue compounds are uncommon in nature, so many species that are blue actually achieve the color through larger structures made up of multiple molecules that reflect the blue spectrum of light like the nanocrystals mentioned here Blue morpho butterflies use something a bit different, a series of ridged indents with the angle of the ridges corresponding with the wavelength of blue light
Feb 16 5 tweets 2 min read
Don't put off eating your first meal until the evening

Don't eat your last meal right before bed Eating late at night is associated with worse metabolic outcomes while eating mostly earlier in the day improves them
Feb 16 7 tweets 2 min read
Another hole in the "the Inuit don't have heart disease" argument… This is the oldest study I've found looking at CVD in the Inuit and they note the same plaque seen in the 500 year old mummies

By the time anyone was even collecting data here though most were eating 10-30% non-traditional foods so this gets written off…
Feb 16 16 tweets 4 min read
Satiation is one of the most under-discussed factors is selecting healthy food, while things like glycemic index are overhyped

Especially if you're trying to lose weight, how full you feel after eating a certain amount of calories can make or break your ability to

(thread) I would even argue that while cardio is often promoted for weight loss, satiation vs. caloric density of your meals has a larger impact

Most successful elimination diets leverage this, people lose weight on veganism, keto, etc, in large part because they're highly satiating
Feb 14 14 tweets 4 min read
A few clinical trial on the benefits of sunlight and its components (isolated UV or infrared light): This is a really cool one, in first grade students spending 11 hours out in the sun per week was associated with less myopia overall and 54% lower risk of rapid myopia progression

Probably stems from a combination of bright light and long distance viewing
Feb 14 5 tweets 2 min read
One of the coolest examples of quantum biology is the sense of smell… There was a long standing theory that smell was a result of the shape of a molecule, in a sort of lock and key mechanism with receptors, however there are many holes in this

A better model seems to be correlation in the Raman spectra readings of molecules…
Feb 13 5 tweets 2 min read
A lot of cell/rodent research on lipid oxidation byproducts focuses on "negative" effects like apoptosis or immunosuppression, but there's some really interesting hormetic effects in some cases as well

12,13-DiHOME, a byproduct of omega-6 oxidation, is particularly interesting It seems to play a role in cold thermogenesis

Increases in it correlate with less insulin resistance, lower blood glucose, better leptin signaling, and lower blood triglycerides…
Feb 13 29 tweets 8 min read
I've spoken about this before here and there, but I have quite a few issues with the "cardiolipin oxidation" model of why linoleic acid is claimed to be toxic

This isn't an attack on RootCauseDoctor or any specific individual, I'll just be digging in to cardiolipin research For the sake of simplicity I'll mostly just pull papers to show how all the available studies stack up here in regards to cardiolipin, linoleic acid, and mitochondria

For those that don't want to read the studies skip to the tweet labelled *TL;DR*
Feb 10 4 tweets 1 min read
Yep, though just to be clear BPA isn't formally banned, at least in the US

BPA-free plastics are the company's response to individuals fearing the harms of BPA and talking about it, you see the same thing with pthalates, sulfates, etc It's likely that we will continue to see this cycle

In 30 years there could companies adverties "x chemical" free products, based on some research that comes out about compounds we've never heard of today
Feb 9 25 tweets 5 min read
Story time:

Years ago I was working at a "plant-based" restaurant, at the time I was still buying into the idea that veganism was optimal, very very early in my nutrition research Over time I began to notice that almost every time I would eat the food from this restaurant for my shift meal I would sink into a deep depression, complete with suicidal ideation

This happened every. single. time. and finally I connected it to a particular ingredient
Feb 7 5 tweets 1 min read
Reposting a few of my favorite blogs I've written on quantum biology here for anyone interested DHA: nature's favorite semiconductor…
Feb 5 4 tweets 1 min read
Here's an interesting study in rodents

When mice are given more omega-6 in the short term, then switched to a high fat diet to elevate their lipids, they actually had less oxidative damage to their arteries and higher antioxidant levels, a hormetic effect The interesting thing is that oxidative byproducts were elevated indicating that oxidative stress did occur, but this was not paired with any expected damage

Catalase was increased to a large enough extent to protect against this, and this persisted even after switching diets