$nktr $crvs Long thread that explains mechanistically and empirically why rezpeg is the most elegant and likely safest approach to controlling Th2 driven diseases.

Starting with worms. 1/13 Chronic helminthiasis was ubiquitous and endemic throughout human evolution. We all were infected with helminths, often multiple types at once, most of the time. The immune response that evolution developed against this was the Th2 response. 2/13