Went home this diwali , decided to convert an old ASUS laptop into a homelab server that I could access remotely.
The idea : host self-hosted apps, VPN, and media servers

First, I made the internal IP static. Went to Ubuntu Wi-Fi settings > IPv4 > Static IP. Set a static addres Now, the laptop's IP doesn't change after reboots.
Next problem was external IP

Sadly Getting Static ip was too much hassle, so hosting apps with a mapped domain wasn't possible.

DNS providers like DuckDNS are cool, but meh—I wrote my own Dynamic DNS management in node.js

lets deal with this mf now:
so the code has some functions,classes that do some stuff for us caveman's , Awoooga.

also python strong 💪, java weak ☹️

#StereoEnumerationOptions a class->configs how stereoisomers to be generated (you can pass params) 😇 github.com/rdkit/rdkit/bl…
then we have some helper classes, these will be called by others to do :

_BondFlipper-> flips the stereochemistry of a bond
_AtomFlipper -> flips the stereochemistry of an atom.
_StereoGroupFlipper-> flips stereochemistry of a group of atoms associated with a StereoGroup.

the working of the function- `AllChem.EnumerateStereoisomers(input_molecule)`

input -> a SMILES string()
string is first parsed into a RDKit molecule object.
you also use diff params:

-include_cistrans( for geometric isomer)
-include_optical(enantiomers) shorturl.at/qsxG0

https://twitter.com/corvus_ikshana/status/1698701553727873100

internal working for stereoisomers:
- function generates stereoisomers by trying diff combo's( different stereochemical configurations) with rules followed:

1- Chirality : for those with chiral centers, func try's for two possible configurations: R (right-handed) ,S (left-hnd)

yesterday I was able to generate isomer's of some compounds , the input I have 2,3-dichlorobutane in a "SMILE format".
my main focus is on pantoprazole currently.
Those who had GERD or acidic reflux in stomach might have taken this drug.
Its a type of Proton-pump inhibitor.





it binds and forms a covalent bond with something called a proton pump in your stomach and stops the production of H+.
it works like a key and lock thing.
key: pantop and lock : the pump (👉👌)

pretty sure I will fail cause isomers have diff structure and it won't bind same way

wanna know another way to identify viral diseases:
This was used during Covid-19 time , to find what family did Covid came from and if you had it.
remember RT-PCR thing : getting the initial sequence is the tough, time taking costly part, rest is fast.
India didn't had many labs initially for sequencing , and we struggled for testing .
lol my biotech prof struggled to format the RNA sequence to use it in BLAST.
Python came really handy there.