Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Crow 𓄿 Profile picture
Crow 𓄿
@corvus_ikshana
JavaScript kiddie at NSA part time cat girl , nyaa. Gib me moni
Nov 16, 2024 • 11 tweets • 4 min read
Went home this diwali , decided to convert an old ASUS laptop into a homelab server that I could access remotely.
The idea : host self-hosted apps, VPN, and media servers

First, I made the internal IP static. Went to Ubuntu Wi-Fi settings > IPv4 > Static IP. Set a static addres Image Now, the laptop's IP doesn't change after reboots.
Next problem was external IP

Sadly Getting Static ip was too much hassle, so hosting apps with a mapped domain wasn't possible.

DNS providers like DuckDNS are cool, but meh—I wrote my own Dynamic DNS management in node.js Image
Sep 5, 2023 • 6 tweets • 3 min read


lets deal with this mf now:
so the code has some functions,classes that do some stuff for us caveman's , Awoooga.

also python strong 💪, java weak ☹️

#StereoEnumerationOptions a class->configs how stereoisomers to be generated (you can pass params) 😇 github.com/rdkit/rdkit/bl…
Image then we have some helper classes, these will be called by others to do :

_BondFlipper-> flips the stereochemistry of a bond
_AtomFlipper -> flips the stereochemistry of an atom.
_StereoGroupFlipper-> flips stereochemistry of a group of atoms associated with a StereoGroup. Image
Sep 5, 2023 • 5 tweets • 2 min read
the working of the function- `AllChem.EnumerateStereoisomers(input_molecule)`

input -> a SMILES string()
string is first parsed into a RDKit molecule object.
you also use diff params:

-include_cistrans( for geometric isomer)
-include_optical(enantiomers) shorturl.at/qsxG0
internal working for stereoisomers:
- function generates stereoisomers by trying diff combo's( different stereochemical configurations) with rules followed:

1- Chirality : for those with chiral centers, func try's for two possible configurations: R (right-handed) ,S (left-hnd)
Image
Image
Sep 4, 2023 • 5 tweets • 3 min read
yesterday I was able to generate isomer's of some compounds , the input I have 2,3-dichlorobutane in a "SMILE format".
my main focus is on pantoprazole currently.
Those who had GERD or acidic reflux in stomach might have taken this drug.
Its a type of Proton-pump inhibitor.


Image
Image
Image
Image it binds and forms a covalent bond with something called a proton pump in your stomach and stops the production of H+.
it works like a key and lock thing.
key: pantop and lock : the pump (👉👌)

pretty sure I will fail cause isomers have diff structure and it won't bind same way
Image
Image
Aug 26, 2023 • 4 tweets • 1 min read
wanna know another way to identify viral diseases:
This was used during Covid-19 time , to find what family did Covid came from and if you had it.
remember RT-PCR thing : Image getting the initial sequence is the tough, time taking costly part, rest is fast.
India didn't had many labs initially for sequencing , and we struggled for testing .
lol my biotech prof struggled to format the RNA sequence to use it in BLAST.
Python came really handy there. Image