Private practice neurologist and trialist. The line separating smart and dumb passes right through every human brain.
Jan 1, 2020 • 6 tweets • 2 min read
I don't get this article. It states "declines in memory and thinking seen in Alzheimer's patients [sic] tend to occur before amyloid plaques." By which it means declines seen in a category called Subtle Cog Difficulty (SCD). upi.com/6970279t
But the article actually concludes "SCD may be a sensitive and non- invasive predictor of encroaching amyloidosis... prior to frank cognitive impairment associated with MCI." n.neurology.org/content/neurol…
Mar 25, 2019 • 12 tweets • 3 min read
1. Reports of the death of the amyloid hypothesis are exaggerated. Here's why. statnews.com/2019/03/21/alz…2. Background: two Biogen Alzheimer trials failed using an monoclonal antibody that looked like it engaged amyloid with a unique binding interface. This was an important trial. Disclosure: I did not participate as a site PI for them but do others. alzheimersanddementia.com/article/S1552-…
