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deWitLab
@deWitLab
Computational Genomics Lab studying 3D genome function and dynamics @ Netherlands Cancer Institute and Oncode | Post-doc and PhD positions available in 2020
Aug 12, 2019 • 10 tweets • 8 min read
Very proud to present the lab’s first bioRxiv preprint: biorxiv.org/cgi/content/sh… Great collaboration between @benoitbruneau and @ElphegeNoraLab. Main gist is that WAPL is important for maintaining dynamic cohesin to bring promoters and enhancers together. Digest in the thread. @benoitbruneau @ElphegeNoraLab 1/9 Using the auxin inducible degron (AID) system we acute depleted the cohesin release factor WAPL from mouse ESCs. Within 1 hour WAPL is lost. This leads to morphological changes that suggest differentiation. Alkaline phosphatase staining suggests a loss of pluripotency.