New study on changes in mitochondria in Long Covid.

1️⃣Increased ROS (super oxide dismutase 1), … note Taurine can help counteract
2️⃣changes in mito recycling (mitophagy) and
3️⃣a potential biomarker: lower amounts of circulating free mito dna… could be used as a test Link to mitochondrial change in long covid article with 3 main findings.

link.springer.com/article/10.100…

#MEspine2024 pieces of the me/cfs puzzle from talk
A 🧵

Big picture = out of control brainstem feedback (& lots of jargon/names get in the way of the understanding!)

🔔Inflammation/mechanical block limits blood flow

Low flow causes hypoxia

Hypoxia causes ongoing inflammation 2/n

1) a combination of things impact the brainstem mechanically & via post infection inflammation & low blood flow/oxygen inflammation

2) the combination can degrade collagen via the inflammation and in the process, create more mechanical instability/pressure.

Antivirals with anti-sars capabilities:

We will finally know what works via trial for truvada.

Truvada = $20/mo
(and might work better)

Paxlovid = $1300 for 2 weeks.

Funded study of antiviral tx in long covid announced that tests truvada and will also look at marovirac

https://twitter.com/polybiorf/status/1760674287541977378

Here.s an approach to address steps in the long covid puzzle using proven drugs/supplements that are cheap, safe and accessible.

This like many approaches is not proven.

Sharing as FYI to use or not as makes sense. A 🧵

1) antiviral 2) TLR4 antiInflamm 3) micrclot breaker

“Smoking gun” articles together re:brain fog #longcovid

spike binds TLR4. TLR4 activation causes memory issues.

AND IS REVERSIBLE at least in mice! DrT post shows flow process.

There are lots of ways to quiet TLR4 activity (curcimin, metformin, berberbine, LDN etc)

https://twitter.com/chydorina/status/1736978757280465293

Link to article showing TLR4 and mechanism of cognitive impairment. Mediated by Complement 1q and others processes. cell.com/cell-reports/f…

Taurine and mitochondria and effectiveness in patients with impaired cardiac function, 2 articles: 1) overview 2) clinical trial with ~25% increase in exercise capacity and cardiac output after 2 weeks of 500mg 3 times a day of taurine. #longcovid #mecfs doi.org/10.3390/molecu… 2/2. Exercise capacity increased ~25% after 2 weeks of 1.5mg/day or taurine vs placebo. Small number of patients, 29. Heart failure. Also echo showed increased cardiac output. journal-of-cardiology.com/article/S0914-…

Long Covid study shows TLR4 inflammation is at the core of the disease. Stop/Reverse to end the feedback loop causing ongoing downstream issues of inflammation and micro-clotting . Multi prong approach should work. Antiviral, TLR4 block, Fibrin break up, Probiotics… What Else? Link to original study on long covid cause. medrxiv.org/content/10.110…

@organichemusic interesting article on melatonin as a therapeutic for #longcovid. Can you include a melatonin try/efficacy question in an upcoming survey? Or if someone has tried melatonin for. LC with success or failure please share observations in this thread. Thx! Melatonin as therapeutic in #longcovid. mdpi-res.com/d_attachment/b…