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Abdel Abdellaoui Profile picture
Abdel Abdellaoui
@dr_appie
Complex Trait Genetics | Population Genetics | Evolutionary Genetics | @AmsterdamUMC | @UvA_Amsterdam
Sep 16, 2025 • 9 tweets • 4 min read
The largest study on late life virginity, based on > 400k individuals, out now in @PNASNews

Open access link:

Shoutout to shared first author @laurawesseldijk ❤️

Thread below 👇🏽 pnas.org/doi/10.1073/pn…Image Sex is central to human wellbeing.

~1% of people never have sex. While some people simply don’t want sex, for others, no partner can mean loneliness, lower wellbeing, or even economic disadvantage.

No sex is also interesting for genetics as it is an evolutionary “dead end”. Image
Jun 21, 2025 • 9 tweets • 4 min read
Studying the genetics of intelligence measures can help us understand the neurobiology of cognition and neurodevelopmental conditions 🧬🧠

We estimated missing intelligence test scores in @uk_biobank to reduce bias and boost power.

Preprint:

Thread 👇 medrxiv.org/content/10.110…Image For additional context, we’ve written a lay summary and FAQ that explain the study and how the results can and can’t be used or interpreted: medrxiv.org/content/medrxi…Image
Mar 26, 2025 • 17 tweets • 5 min read
In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @NatureHumBehav 💰🧬🎓

Link:

Thread below 👇🏽 rdcu.be/efacKImage This thread summarizes our key findings, but Twitter's format necessitates some simplification and jargon. For a more comprehensive and nuanced understanding of this complex topic, I encourage reading the full paper, which we've written to be accessible to a wider audience.
Aug 22, 2022 • 11 tweets • 5 min read
We tend to reward people with certain genetic propensities with better environments (higher SES 💰). This results in gene-environment correlations that make society more unequal and further complicate studying human genetics.

Out now in @NatureGenet: nature.com/articles/s4158…
🧵👇🏽 Image Genes associated with complex traits are not distributed randomly across geographic regions. Especially genes associated with education show regional differences in line with SES, at least in part due to migration. More on that in this older thread:
Oct 21, 2019 • 15 tweets • 13 min read
Our study on the geographic distribution of human DNA in Great Britain is out in @NatureHumBehav.

You can download a general summary and FAQ document here: scribd.com/document/43055…

The article is here: nature.com/articles/s4156…

And a thread explaining the main findings below 👇🏾 @NatureHumBehav We looked at the geographic clustering of ancestry differences and complex trait variation. As expected, ancestry differences show very strong geographic clustering and very nice geographic patterns, many roughly separating Wales, England, and Scotland. 2/15