Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Dr Kevin Lee Profile picture
Dr Kevin Lee
@dr_kevinlee
Not medical advice❤️/RT≠endorse
Jan 25 • 11 tweets • 2 min read
#MyalgicEncephalomyelitis #MECFS as a Two-System Network Stalemate Hypothesis:
Bottom-up Energy Crisis ➡️ meets ⬅️ Top-down Brake Failure.
When cellular energy fails, the brain’s switch flips: GABA calm flips to hyperarousal
Result? Brownouts (PEM, fatigue etc) a 🧵 Bottom-up Crisis
Structural vulnerabilities (eg vascular compressions, connective tissue laxity) → leaky capillaries + hydrostatic back-pressure → “wet soil” substrate.
This sets the stage for decades—compensated but vulnerable.