A very enlightening talk by Angela Hutner on simple vs complicated UTI definitions
Simplicity wins
Anything that is beyond the bladder = complicated UTI (including prostatitis)

This will be updated in 2024 by both the IDSA and ESCMID

#IDTwitter #IDXposts

IDSA/ESCMID new guidelines:

New drugs against GNB by Ursula Theuretzbacher #ECCMID2023

In Malaysia, we only have Cefta-avi for resistant GNB infections!
We hope @SHIONOGI_JP will include Malaysia in the list of countries for generic cefiderocol- a project by @gardp_amr

@KKMPutrajaya @DrZalihaMustafa These are the drugs that are recently approved and we have none of these locally
We can only use Fe-troja(n)/Cefiderocol by @SHIONOGI_JP under the compassionate use program, and the drug is flown all the way from Europe

The cost is huge and our patients can rarely afford it

Fairytales or reality, checking some eminence paradigms for treatment of severe infections

#ECCMID2023 Kill fast! These infections must be treated with a "bactericidal" antibiotic
Beatrice Grabein, Germany

Clindamycin is bad for invasive MRSA infection
journals.asm.org/doi/full/10.11…

Polymyxins and carbapenems: their place in the treatment of MDR Gram-negative infection today
#ECCMID2023

This a very relevant talk for us in Southeast Asia (exc Singapore)

@alif82 @SyamhaninA @fikreeahmad @shaharudeen @GSRajahram @stevenlimcl @SazaliBasri @HanzHc

Evolution of CM/ID Specialties by Dr. Rama
#ECCMID2023 He talked about his evolution when he came back from the US and the UK
He needed to learn about the cultures in India

This includes antibiotics as a one-size-fits-all remedy

He captured the issues of empiric therapies - one empiric regimen after another.

Tricks and tips for the infectious diseases consultant by Esther CALBO, Spain at #ECCMID2023

Risk of death for ID physicians from "womb to tomb." Our role is essential (ID consult can reduce the risk of death)

However, we must know how to sell our importance to the hospital suite

Does AMR increase the risk for bacteremia recurrence?

Session: Impact of antimicrobial resistance on the risk of recurrence after community-onset bacteremia
Speaker: Salam Abarra

#ECCMID2023

Risk factors for persistent bacteremia in patients with GNB BSI: an SR with meta-analysis
Do you do a FUBC in GNB patients?
@alif82 (something that might interest you)

QnA: How freq was the FUBC in these studies?
Variable ways of FUBC in all the included studies

#ECCMID2023 Methodology 1

SAFO Trial in #ECCMID2023
Main findings:
Shorted duration of bacteremia
But similar mortality
As per predicted by @DrToddLee

QnA:
How many were complicated vs. unc.
The majority were unc.

Sec outcome of persistent bacteremia was defined as bacteremia > 72H Why Fosfomycin?

Another gem from IDWeek 2022

Increased incidence of colorectal cancer in Veteran Health Administration hospital patients with pyogenic liver abscess

#IDTwitter The rationale and the lit review

In Ceftriaxone-resistant HECK-Yes (esp E. cloacae, C. freundii, and K. aerogenes) with a Cefepime MIC of ≤ 4 mg/L

What is your Rx of choice?

@stevenlimcl @andrewchangID @shaharudeen @HanzHc @SazaliBasri @adammashraff @fikreeahmad @ummuafeera @stevenlimcl @andrewchangID @shaharudeen @HanzHc @SazaliBasri @adammashraff @fikreeahmad @ummuafeera The answer is not straightforward it seems
cc @afranahdia

This letter to the editor argued Cefepime/FEP shudn't be used for such isolates

Data: Lee et al. data (Taiwan)
ESBL E cloacae were identified even when the FEP MIC ≤ 2 mg/L (44% of them)

dropbox.com/s/36uokdwqyygo…

Myth: Bactericidal Agents Are Necessary for the Treatment of BSI at #idweek2022

A nice and easy-to-follow account of bactericidal vs. bacteriostatic agents and activity
@SyamhaninA @fikreeahmad @adammashraff @shaharudeen @andrewchangID @Rasidah @suraya_sudenia @cllau888 @SyamhaninA @fikreeahmad @adammashraff @shaharudeen @andrewchangID @Rasidah @suraya_sudenia @cllau888 Cidality is NOT an intrinsic property of an antibiotic
e.g., for the same drug (TMP-SMX), we have 2 different properties against 2 different organisms:
1) Static against Steno
2) Cidal against E. coli