Pediatric Moratorium! Adult Use Restrictions! Veterinary Prohibition!
"Codon Optimization in mRNA Vaccines and Gene Therapies: An Assessment of Protein Misfolding Risks and Regulatory Oversight" submitted to the FDA's Vaccines and Related Biological Products Advisory Committee!
Here's the Executive Summary

Objective: This white paper evaluates the scientific evidence and regulatory oversight related to codon optimization in messenger RNA (mRNA) vaccines and gene therapies for both human and animal applications. Its primary goal is to assess whether the potential risks—specifically protein misfolding, aggregation, and associated diseases like amyloidogenesis and prionogenesis—justify a moratorium on this technology’s use. The analysis aims to inform policy by balancing innovation with safety.

Scope: The assessment covers the principles of codon optimization, the mechanisms of protein folding and misfolding during translation, and the risks of amyloid formation and prion-like propagation. It reviews regulatory frameworks, including the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) Chemistry, Manufacturing, and Controls (CMC) requirements. The scope includes a detailed examination of scientific literature—both foundational and recent—such as studies on tissue-specific codon usage, codon context effects, and structural risks in mRNA vaccines. It also analyzes preclinical and clinical safety data, pharmacovigilance reports, and a case study on COVID-19 mRNA vaccines. Additionally, the paper explores implications for veterinary vaccines and food chain safety, concluding with an updated risk management and policy evaluation.

Key Findings: Codon optimization enhances protein production in mRNA-based vaccines and therapies but introduces risks that challenge its presumed safety. New research shows that changing codons—previously thought to be neutral—affects translation speed and accuracy, potentially leading to protein misfolding and aggregation. For example, the cardiomyocyte PAO model reveals that misfolded proteins can cause delayed, severe damage, such as heart failure, broadening concerns beyond brain-related diseases. Data from TissueCoCoPUTs indicate that generic codon optimization often mismatches the translation needs of specific tissues, increasing misfolding risks. In COVID-19 mRNA vaccines, structural issues like excessive G-quadruplex formation may heighten these dangers.
Regulatory oversight, however, falls short. There are no standard tests to evaluate how codon changes affect protein shape or clumping, and long-term monitoring is insufficient to detect slow-developing issues like neurodegeneration or prion-like diseases. The rapid rollout of COVID-19 mRNA vaccines lacked thorough evaluation of these folding risks. In veterinary applications, the use of codon-optimized therapies in livestock raises unresolved concerns about misfolded proteins entering the food chain and environment, potentially affecting human health.

Conclusion on Moratorium
Given the mounting evidence of risk and gaps in oversight, a tiered moratorium is recommended as the most cautious and effective approach:

· Pediatric Moratorium: Codon-optimized mRNA vaccines and gene therapies should not be used in children under 18 until safer practices are developed. This includes using tissue-specific codon designs, conducting 24-month safety studies in primates, and setting limits on G-quadruplex formation. Children’s developing tissues are especially vulnerable, and long-term data are lacking.

· Adult Use Restrictions: New clinical trials for risky mRNA designs—those with heavy optimization, high clumping potential, or rich GC content—should pause. This halt would last until advanced tests, such as Kinetic Folding Assurance (KFA), hidden gene screening, and cross-seeding checks, are required.

· Veterinary Prohibition: Codon-optimized gene therapies in animals entering the food supply should be banned. Evidence from the PAO model and prion diseases suggests a risk of transmissible misfolded proteins, posing a threat to food safety.

This moratorium should persist until:
· Reliable tests for protein folding and clumping are part of regulatory standards.
· Codon optimization accounts for tissue-specific needs and translation timing.
· Independent research verifies the safety of high-risk designs and pediatric use.
· Better monitoring systems track long-term health effects.

This approach marks a shift in how codon optimization is viewed: it’s not just a tool for efficiency but a process that demands careful study of its effects on protein structure and safety over time. By adopting these measures, we can protect public health while still advancing mRNA and gene therapy innovations.


The whitepaper has just been published in my Sub/I\Stack (Link in my pro/I\file)!

🚨Microwave Ovens Might Be Risking Your Health! 🚨
Did you know that eating microwaved food could cause blood changes linked to cancer? Russians knew it. Swiss scientist Dr. Hans-Urich Hertel discovered this over 30 years ago, but the microwave industry tried to silence him.
🧵 Dr. Hans-Urich Hertel was a Swiss food scientist who challenged microwave safety. In 1989, he teamed up with Professor Bernard Blanc to study how microwaved food affects us. Their findings? Alarming enough to spark a decade-long battle! #ScienceHeroes #MicrowaveResearch

Iran’s leaders aren’t just building nuclear weapons for power—they’re building them to trigger the end of the world. This isn’t geopolitics. It’s prophecy, and we’re all targets. Buckle up for a thread that’ll shake you awake.
🧵 1/20 Shia Islam has a figure called the Mahdi—a messiah who’ll return to bring justice and peace. Beautiful, right? Except Iran’s ruling clerics don’t just wait for him. They believe it’s their job to force his arrival. And they’re deadly serious.
🧵2/20

THE GLOBAL IT OUTAGE YOU WITNESSED WAS NOT AN ACCIDENT!
IMPORTANT! The purpose of this thread is to explain non-IT and to non information/cyber security professionals why I believe the outage you are seeing around the world due to the update from #Crowdstrike is not an accident. Before we begin - introduction.
Hi everyone. My name is Ehden Biber. I'm known as the person behind #PfizerLeak, and most of my writing here on X/Twitter has been on ph@rma related topics. HOWEVER, my professional work has been information security and cybersecurity.

"MEDICAL GENETICS…WILL BE THE SOUL OF PERCISION MEDICINE IN EVERY FIELD"
It is time to expose another member of the W.H.O. science council and her views on genomics and gene therapy (mRNA). Introducing Dr Mary-Claire King.

[Thread]
[1/7]: [2/7]
Doctor Mary-Claire King is a very known geneticist who has discovered in 1990 BRCA1,which was the first gene for a hereditary form of breast cancer. She is a professor of genome sciences in the university of Washington, Seattle, USA.
medgen.uw.edu/people/mary-cl…

THE COUNCIL: INTRODUCING THE W.H.O. SCIENCE COUNCIL THAT IS ABOUT TO CONTROL YOUR LIFE.
As we approach the final stages of the #WHO coup d'état attempt, it is time to expose the group of unelected people who will control your future and their alarming agenda!
#TheCouncil
[Thread] 2/
In December 2023 the WHO produced a report that sets the stage to radical changes that soon will be enforced all the citizens of the world: make gene therapy (mRNA) key technology in the fight against infectious diseases, cancer, and combat any resistance to such technologies.

@robinmonotti 1) He uses the exaggerated Hamas dataset.
2) He uses a definition of children for anyone under 18 years old.
3) He say Palestinians were expelled in 1948, but don't mention many left because Arab nations told them to so they can butcher Jews in the war they started.
More below. @robinmonotti 4) He compare the number of children who died to the sum total of children died 3 years before. He does not compare it to the number of children who died in other conflicts IN THE REGION, such as in Syria. That like comparing apples and pears.
More below.

THE AZ STUDY: Why did AZ asked to withdraw their EUA marketing authorisation approval, and how come you didn't hear about it?
Short answer: BECAUSE THEIR LONG TERM SAFETY STUDY SHOWN THAT THEIR COV!D19 SH0TS K!LLED AND HARMED PEOPLE.
Long answer: READ THE THREAD!
#TheAZStudy
1/

2/
As you might have heard, AstraZeneca ASKED in March 2024 to have their COV!D19 SH0TS product approval withdrawn from Europe's EMA. It was not the European Union (EMA) who decided to withdraw their approval due to the damage they caused people. BUT WHY?

ec.europa.eu/health/documen…

MURDER, THEY PLANNED.
The mechanism in which the spike protein impacts the mitochondria, and how it leads to myocarditis, heart attacks, cancer, and neurological disorders such as face paralysis, Alzheimer and Parkinson's disease.
Highlights from my latest article.
[THREAD]
1/ 2/
In order to encode proteins (including the spike protein), the cells are using a mechanism called tRNA so that the ribosome could translate the mRNA sequence to a protein (or more correctly, to translate each codon to an amino acid).

THE PFIZER LAB: THE GAZA WAR EDITION.
[THREAD]
#Pfizer is AGAIN using Israelis as a laboratory rats to test its products, AGAIN the Israeli ministry of health and Israeli doctors are taking part and AGAIN patients are not being informed that they are lab rats.
#Fosmanogepix 2/
My 1st tweet included a translation from Hebrew of a tweet that was posted today by @MaytalYasur, the health correspondent of an Israeli newspaper called @israelhayomheb.
#Fosmanogepix

https://twitter.com/MaytalYasur/status/1739611735575724191

@Kevin_McKernan @MEGAprivacy Kevin, as a privacy expert, I strongly advise you to take look at this, about the NZ Privacy Act 2020. I would love to help!

dataguidance.com/notes/new-zeal…




@Kevin_McKernan @MEGAprivacy The most crucial point to start with - PRIVACY LAWS DO NO APPLY TO DEAD PEOPLE. Therefore, if the dataset included ONLY information on people who died, the NZ Privacy Act does not apply to them, even if data such as name was exposed!

DEBUNKING "MYSTERY", THE "DOCUMENTARY"
[THREAD 1/X]
HERE ARE FACTS:
1) Hamas was NOT created by Israel SEE LINK!

2) there are Muslims brotherhood branches in Israel. Also in Europe.
3) The Muslim brotherhood have a social and a military, secret portion.

https://twitter.com/eh_den/status/1716714807083024584

https://twitter.com/Thomas_Binder/status/1716934894067052802

2/
4) Israel supposed Ahmed Yassin movement on the social side as a counter organization to the PLO, in an attempt to reduce its influence in Gaza. That was BEFORE Hamas was established. Read their charter from 1988 to see what Hamas is and what are their goals.

WHO IS RESPONBIBLE FOR THE FAILURE TO WARN AGAINST THE #HAMAS ATTACK?
Retired police commander Avi Weiss has just given an interview in Hebrew to explain what has happened on the 7th of October, and who bears the blame. Here are his SHOCKING revelations!
[THREAD]
1/
#IsraelAtWar 2/
According to commander Weiss, there are 4 intelligence gathering doctorines:
Open source intelligence (OSINT)
Signals intelligence (SIGINT)
Visual Intelligence (VISINT)
Human intelligence (HUMINT)

Out of these 4, 3 are under the responsibility of the #Shabak (שב"כ)

EXPLOSIVE!!!
1) ISRAEL MINISTRY OF HEALTH ADMITS THAT #MYOCARDITIS (WITH OR WITHOUT #PERICARDITIS) OCCURS IN 1 IN 6637 YOUNG PEOPLE BETWEEN THE AGES OF 16 TO 19 WHO GOT #COVID19 VACCINES!
2) THEY ADMIT THAT ADVERSE EVENTS ARE MORE COMMON WITH YOUNG PEOPLE!!!
1/THREAD
#mRNAGate

2/
What you are about to read is part of a product insert by the @IsraelMOH for the #Moderna XBB variant "vaccines" that Israel has bought to "vaccinate" its population. It was created & distributed on the 28th of September 2023.
THIS IS PART 1 OF THE EXPOSURE.
#mRNAGate

EXPOSED: What is the secret cult that trained Shira Eting, the "social activist who builds on climatetech and healthtech", who is also one of the prominent activists in the protest movement against the legal reform and the chairman of 555 of the pilots' organization?
THREAD
1/ 2/
Shira Eting has been at the centre of CBS's #60Minutes segment about the struggle to reshape the Israeli judiciary system. The segment, entitled "Netanyahu’s push to weaken Israel’s Supreme Court divides nation" missed one "little" fact about her past.

1/4 IMPORTANT REMINDER: I EXPOSED ON JULY 2021 the #Pfizer/#BioNTech manufacturing and supply agreement with Brazil, PROVED IT WAS 100% GENUINE, and provided evidence that ALL THE COUNTRIES AROUND THE WORLD COMMITTED TO THE SAME TERM.
#PfizerLeak
t.me/eh_den/775 2/4
The South-Africa contact which just been exposed via court order only proves that everything I've written was true & in line with the testimony of the head of Pfizer in Latin America, which I reported on on July 2021. Here's the testimony:
#PfizerLeak t.me/eh_den/653

LAHAINA FORENSICS: PROOF OF CRIMES, AND WHY IS A BURNING TREE IS IMPORTANT? [THREAD 1/x]
we know that a tree was on fire at around 3:40pm on Lahainaluna Rd. in #Lahaina. "Who cares", right? WRONG. SO WRONG!!! Read why below
#LahainaFires #MauiFires #lahaina

02/
If you haven't read my previous thread, PLEASE read it now:

ANYONE who lived in the centre-"upper" neighbourhoods of #Lahina (upper to Honoapiilani Highway HI-30) HAD to pass next to the tree unless they took the bypass. "so what", right? You'll see! https://t.co/y89mXN7s2O

https://twitter.com/eh_den/status/1691671334323966395

1/X
INVESTIGATION: WAS AN ENERGY WEAPON USED IN LAHAINA?
The mystery lies in this tree trunk, that BURST INTO FLAMES around 3:40pm on the day of the #LahainaFires/#MauiFires.

EXTREMELY IMPORTANT thread. please share it! LOOKING FOR AN ANSWER!

[THREAD]



2/
This analysis was created thanks to a family who one of its members decided to document their evacuation. I found it on twitter in 3 parts (see link below). At 1:11 timestamp of the 1st video there was a 3 seconds video of a tree trunk on fire.

https://t.co/lLr0YTymgM

https://twitter.com/Truthpole/status/1691494473124245504

#COVID19 VACCINES AND #PARKINSON'S DISEASE:
In the 33 history of VAERS for all vaccines, 104 of the 106 cases which reported on the disease were from the COVID vaccine!
The thread will explain HOW AND WHY ONE supplement deficiency (#Niacin) is DIRECTLY RELATED to it.
[THREAD]
1 2/
This thread will start with quick overview of Parkinson's Disease (PD), and will focus mainly on why #niacin (#NicotinicAcid) deficiency is directly related to the disease. Huge kudos to Steve Kirsch for his #VAERS finding.

https://twitter.com/stkirsch/status/1682190024731947008

#ISRAEL: CLIMATE #LOCKDOWN HAS BEGUN!
The Israeli Nature and Parks Authority has just informed that due to "extreme weather conditions" they are 'closing down' many of the trekking trails around the country EVEN THOUGH THEY HAVE NO LEGAL AUTHORITY TO DO SO.
THREAD 1/
#Agenda2030

2/
The Israeli Nature and Parks Authority is an authority that was created in 1998 to preserves the values of nature, landscape and heritage, and connects the person to the place with an affinity and belonging to the Land of Israel.

parks.org.il/about/

Either Elon is lying, or he needs to fire his #infosec/#cybersecurity team!

Elon sent out a tweet today saying that in order "to address extreme levels of data scrapping & system manipulation" they applied a temporary bad.

I call bullshit.
The next tweets will explain why
👇👇 1) Authorised apps (Android/iOS) have specific measures to protect them, and it allows, with high degree of certainty, for the infosec team to know who is real and who is not. Data scrapping does not come from it, and attempts to perform system manipulation will be seen easily.