I hope people realize we are about to have an H5N1 pandemic. The sequence in BC they dumped the data late last night and it shows it’s picked up the necessary mutation needed to be an efficient human host. It’s highly pathogenic, it’s deadly, and it’s now got what it needs to spread among humans. It’s got the same mutation as 1918 Spanish influenza. Brace yourselves. You can pretend all you want like Covid but the 58% mortality rate won’t care.

Glycine. Amino acid. Neurotransmitter. Inhibitory effects in the brain can alleviate depression, boost concentration, help with brain fog. We make glycine naturally in the spine but if you are deficient in glycine it can lead to hypothyroidism, obesity and diabetes. I think I was deficient in it because I was a vegetarian for 8 years and I don’t eat red meat. I only eat chicken now. I take magnesium glycinate at night to sleep, I take glycine during the day for the brain boost.
It also has anti-inflammatory effect.

“Glycine appears to exert several protective effects, including antiinflammatory, immunomodulatory and direct cytoprotective actions. Glycine acts on inflammatory cells such as macrophages to suppress activation of transcription factors and the formation of free radicals and inflammatory cytokines.” L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent

.pubmed.ncbi.nlm.nih.gov/12589194/#:~:t…

Stinging nettle one of my favourite mast cell stabilizing supplements. My MCAS goes haywire without it and I can eat way more foods when I take it. Stinging nettle reduces mast cell degranulation, and stops the release of pro-inflammatory cytokines by inhibiting tryptase. It’s a natural antihistamine. I think it also helps my joint pain. It also has antifungal properties, antiviral properties and may help with hair loss. Funny enough when I ran out, my hair started falling out again. Back on it and my hair is growing like crazy. This is an interesting article on it

sciencedirect.com/topics/pharmac…

Ummm I have BOTH of the top long covid genetic markers posted in that study on 23&me. HLA-DRB1 and rs9273363. And my long covid has been severe and debilitating right from my first infection, while my acute covid has been asymptomatic or mild. 🤯


This is the full study

medrxiv.org/content/10.110…

Long Covid update

So happy I’m not having anymore brain fog. Between berberine-metformin-taurine-nicotine-maraviroc my neurological symptoms have all resolved

Atorvastatin has really helped my vascular issues. My skin is all a normal colour, not having blood pooling, no weird tingling or numbness.

I’ve got my POTS and MCAS under control.

My autoimmune diseases are under control

My ANS is functioning properly and I’m not having any dysautonomia symptoms

Haven’t had a PEM crash since May

I’m able to go in the sun again without anaphylaxis.

I’m still on a pretty limited low histamine diet. I cannot deviate from my diet to keep my MCAS controlled. Keeping MCAS controlled keeps everything else under control.

Mostly I’ve just got some fatigue from the maraviroc and I’m dealing with pain management from fibromyalgia but even that has gone from a 10/10 pain to 3.

I’m now just dealing with trying to get my CD8 T cells which are hyperactivated back to normal w the maraviroc, get rid of the viral persistence in my monocytes so disease process doesn’t restart, get rid of the rest of the inflammation which is almost gone.

This is definitely the most recovered I’ve felt. I have to say the nicotine patches are keeping my fibro pain under control. I don’t use anything for pain besides the nicotine patches and weed. I am allergic to all opiates. I use Tylenol sometimes. Can’t take NSAIDS. But for the most part I’m using 14mg or 21mg nicotine patches daily. I also think nicotine is an effective mast cell stabilizer and I also think it’s helped my POTS, my HRV has stabilized on nicotine.

People with hEDS and MCAS should be careful with nattokinase. Especially if you have a soy allergy. Natto is made from fermented soybeans. Lumbrokinase is a better option if you have a soy allergy or severe MCAS. Serrapeptase is another soy free option.

Taurine helps rebuild your shortened telomeres by preserving telomerase enzyme btw. It’s helping reverse the epigenetic damage covid did to me. Metformin also helps with epigenetic damage. Resveratrol, Vitamin c, polyphenols, help with telomere shortening. Anything that reduces oxidative stress helps telomeres. Shortened telomeres means your DNA is damaged. Shortened telomeres means you’re aging faster at a cellular level and you will get cancer, age fast and die early. COVID is causing epigenetic aging and telomere shortening. Important to reduce the number of infections you get by wearing a respirator. I had a bunch of grey hairs all of a sudden when my long covid was bad and since I started self experimenting with senolytics like taurine, metformin, berberine, I have fewer grey hairs and my LC has improved. Immune-senescence plays a major role in LC. That’s why everyone who is repeatedly catching covid is aging faster. Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors

ncbi.nlm.nih.gov/pmc/articles/P…

I’m a big fan of Milk Thistle as a mast cell stabilizer. Milk Thistle contains Silibinin.

“Silibinin reduces the production and mRNA expression of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-8, suggesting that silibinin could be used for the treatment of mast cell-derived allergic inflammatory diseases.” ncbi.nlm.nih.gov/pmc/articles/P…

I’m noticing women are getting long covid more often but men seem to be suffering strokes post covid more often. Just from observing people I know, reality tv, anecdotally. My fiancé works in neurology and it’s just constant strokes and brain tumours now. So scary. This is the new normal everyone wanted so bad. Constant illness and disability. A healthy society is a thing of the past. I hope you are all happy with your decision to let a BSL-3 pathogen rip. Condemning everyone to an early grave with lots of suffering along the way.

Seeing way too many people posting about bleeding from the eyes on Reddit for H5N1 to not be spreading H2H. I don’t think it’s going to be as fatal though in mammals as it is in avian species. I’m seeing the same pattern and signs as I did in November 2019 that led me to believe there was going to be a pandemic. I told all my friends to start masking in December 2019.

It’s hard for me to share these photos but I want people to see what this virus can do. These photos are from 2022.

I have been bald since May 2022 when my hair started to fall out after my first Covid infection which was ASYMPTOMATIC. I was diagnosed with alopecia areata, which is an autoimmune response. I lost my hair, brows and lashes. I also had vascular lesions everywhere. I also developed solar urticaria, meaning I’m allergic to UVA/UVB. Indoor lights burned my skin. The sun gave me anaphylaxis. I have not been able to be in direct sunlight in over 2 years. My eyes swelled shut for several weeks.


I can go outside in the shade now at least if the UV is low enough. My hair is starting to grow back for the first time normally. My eyelashes and eyebrows fully grew back. These are all wigs

About to have a video conference with specialists about my lymphocyte panel results. Okay so they confirmed I have long covid viral persistence in my monocytes. Dr. Patterson prescribed HIV antivirals and a statin. The statin can get the spike protein out of the body via apoptosis. I am going to be doing 6 months of Maraviroc and Atorvastatin. Confirms I have vascular inflammation and damaged endothelial cells. He said the spike can persist forever if you don’t clear it. He also said it was not LIVE viral replication. It’s the viral fragments left behind after an infection that cause a cytokine storm.

Sounds mild, right?

My current updated protocol for managing long covid, ME/CFS, MCAS, POTS, Fibromyalgia.

Taurine (powder form 1.5g scoop x2)
Berberine (500mg x2)
Probiotics - lactobacillus plantarum
Arginine (protein powder form 5g scoop)
Glycine (5,000-10,000mg)
Lysine
Collagen Peptides
Magnesium Bisglycinate
Resveratrol (1200mg a day)
High dose vitamin c (1000mg)
Vitamin B2, Liquid B12, K2, B3
High dose vitamin D3 (5,000-10,000ui)
Omega-3
NAC (500mg x 2)
D-Alpha Lipoic Acid w biotin

Mast cell stabilizers:
Pycnogenol (French maritime tree bark) (250 mg)
Quercetin (1000mg)
Spirulina
Stinging Nettle
Olive Leaf Extract
Sweet fennel, milk thistle
Turmeric
Antihistamines: loratadine 10mg x2 (am), famotidine 20mg x2 , hydroxyzine 25mg (pm)
Activated charcoal (as needed to bind mycotoxins & heavy metals)

Propranolol (for POTS)

Gabapentin (200mg x2 for SFN)
Cooper, Zinc, Selenium
Melatonin
21mg nicotine patches worn continuously

I use betadine nasal sprays, CPC mouthwash.

I also do a low histamine diet, no soy, no gluten, low carb, high protein. This protocol I put together helped me go from severe to mild and gave me quality of life back.

https://x.com/erincandy/status/1801245274787946624?s=46&t=67VdfUG2WKw_-l_qm47YLg

I feel so motivated today I’ve already read 14 medical journals. I’m now convinced nicotine helps LC not only because of the theory that it might dislodge viral fragments from acetylcholine receptors, I think it’s also a mast cell stabilizer that can cross the BBB. Everything always comes back to mast cell activation. That is the key to solving LC and ME/CFS

Managing MCAS is a 24/7 job but I’ve got it controlled now that all my LC symptoms are gone and my other autoimmune diseases seem to be in remission. Not getting PEM, usual fibromyalgia pain is gone, my hair is growing, my blood circulation is better. I’m still allergic to UV but it’s slowly getting less severe the longer my mast cells are stable.

I’m doing research now to see if there’s a connection with nicotine and mast cells because my recovery since adding it has pushed me from severe to mild. So far I’ve found that nicotine agonists inhibit histamine release from human basophils so I think nicotine might be a mast cell modulator. “Inflammatory substances released by mast cells induce and maintain the allergic response. The mast cells degranulate rapidly (in seconds) releasing the preformed chemical mediators, including histamine and β-hexosaminidase that play a critical role in the immediate-type allergic response.”

In this study they found that stimulation of FcεRI IgE receptors caused rapid mast cell degranulation (which causes MCAS symptoms). They compared the effects of cromoglycate sodium (a well known mast cell stabilizer) and Nicotine on mast cells.

Cromo Sodium inhibited the FcεRI response by 10-15%. In comparison a low dose of Nicotine inhibited the response by 40-60%! Nicotine is relatively a strong inhibitor of mast cell cytokine production. However because nicotine has such a short half life this study shows that continuous dosing of nicotine is needed to suppress the late stage mast cell degranulation by inhibiting the release of certain inflammatory cytokines.

There are nicotinic acetylcholine receptors on mast cells.

“property of the nAChRs on mast cells might be accessible to novel therapeutic approaches to control allergic diseases and allergic asthma”

Severe MCAS was driving all of my symptoms and since adding nicotine patches, I can’t believe the quality of life I’ve recovered in such a short time.

I focused on calming TLR4 to stop the cytokine storm that was causing systemic inflammation using senolytic drugs. Huge part of my recovery

https://twitter.com/doc4care/status/1802025872800493943

Metformin worked the best

https://x.com/erincandy/status/1756724398185124198?s=46&t=67VdfUG2WKw_-l_qm47YLg

I’ve recovered from long covid twice before and I’m finally recovering again. Things that have been most helpful towards recovery: amino acids, collagen peptides, metformin, antioxidants & nicotine patches. Also supplements with antiviral effect, calming TLR4, treating MCAS. I’m sleeping 7-8 hours a night and my anxiety is gone. Orthostatic intolerance improved. Pain improving. Inflammation battle won. This is a good article on natural antivirals, something to research if you were denied paxlovid bc of eugenics like I was:

Antiviral foods in the battle against viral infections: Understanding the molecular mechanism

ncbi.nlm.nih.gov/pmc/articles/P…

Tested my baseline with the nicotine patches and I had a major baseline increase. No longer getting PEM just existing. Only took 5 days on NRT to get a baseline increase. I had to double my patches to 14mg because my body metabolizes drugs too fast, other people will likely need lower dose. This is not medical advice just my experience

Continuing the nicotine patch test experiment with a patch dosage
increase today to see if I can raise my baseline more. I wore no patches yesterday and my baseline was the same with them. Brain fog, orthostatic intolerance and energy all improved. Most of my LC symptoms are gone

Forever in supplemental debt but these are the only things that have given me any sort of quality of life.

Current MCAS arsenal. (Not pictured are RX meds - Metformin, Propranolol, Gabapentin, antihistamines ( h1&h2). The ones that are making the most difference right now that I would say are my must haves are the Glycine, The Stinging nettle and Spirulina have stopped MCAS flares instantly, Olive leaf and quercetin/BBR. I have only been taking the stinging nettle and spiruilna for a week and my mast cells finally feel like they are stabilizing for the first time since I was reinfected with JN1 in February.

Once you realize that aging is a side effect of immune system damage, you realize why anti-aging drugs help with long COVID symptoms.

Taurine deficiency as a driver of aging

“Aging is associated with physiological changes that range in scale from organelles to organ systems, but we are still working to understand the molecular basis for these changes. Studying various animals, Singh et al. found that the amount of the semi-essential amino acid taurine in circulation decreased with age. Supplementation with taurine slowed key markers of aging such as increased DNA damage, telomerase deficiency, impaired mitochondrial function, and cellular senescence. Loss of taurine in humans was associated with aging-related diseases, and concentrations of taurine and its metabolites increased in response to exercise. Taurine supplementation improved life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.

I do my best thinking on edibles. Who’s ready for a new long COVID thread? Let’s learn about immunosenescence - impact of senescent cells and senolytic drugs! I’ve been focusing my latest research on TLR4, cytokine storms, cell apoptosis and the powerhouse of the cell, mitochondria. As we unravel the web of long COVID, recent research suggests that toll like receptor 4, or TLR4, may be the culprit behind the induction of a proinflammatory cytokine expression caused by the SARS-CoV-2 spike protein activating TLR4. Interestingly enough activation of TLR4 by viral glycoproteins has been seen in EBV, RSV and dengue virus.
The theory is that activation of TLR4 is what is driving the aggressive inflammatory response
of uncontrollable release of high levels of proinflammatory cytokines, increased activation of immune cells, and harmful hyperinflammation seen in long COVID. This cytokine storm causes the damage we’re seeing in long COVID.. dysautonomia, organ damage, organ failure and death. By calming over activation of TLR4 with inhibitors, decreased systemic hyperinflammation could help relieve long COVID symptoms.