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Ethan J. Weiss Profile picture
Ethan J. Weiss
@ethanjweiss
Scientist (metabolism) & Cardiologist (prevention); 2 girls, 1 wife (@PalmerWeiss), 2 dogs; mostly @warriors these days. Latest @Marea_tx
5 subscribers
Feb 24, 2023 • 8 tweets • 2 min read
A story for a Friday afternoon. Spoiler, I really don't know what to do with it.

So I have this patient. He is mid-50's & healthy aside from an ACS event a few years ago for which he was stented & is on all the right 2ndry prevention things. He is also very active He wears an Apple Watch, & a couple of years ago the watch was telling him he had Afib. Given his CAD, this was important as it would mean adding a DOAC to his regimen which of course does not come without risk.

The watch continued to trigger frequent AF alerts and we did a Zio
Jan 13, 2023 • 4 tweets • 1 min read
I don’t understand why people are so bothered by the fact that metabolic disease can be treated by medicines. It’s not that lifestyle solutions can’t work; they can! It’s that they don’t work for a very large number of people… We should celebrate that more people have solutions that can work for them. Not doing so is the height of arrogance
May 20, 2022 • 5 tweets • 1 min read
Anyone else finding it increasingly difficult to tweet anything that does not feel like it is a massive cry for attention? I am overwhelmed by my own self-consciousness here and honestly it is a new phenomenon
Apr 17, 2022 • 5 tweets • 2 min read
Here’s a question for @nicknorwitz & @realDaveFeldman: if I understand, your model hypothesizes that increased ApoB in lean/athletic people on low carbohydrate or ketogenic diets does not result from either 1) saturated fat or 2) genetic variation, but rather from CHO restriction So in the spirit of n=1 case studies, I have one for you. 52 year old male cardiologist BMI 21, exercises 6 days a week, on low SFA ketogenic diet for 4+ years with ApoB ~80 mg/dl
Feb 16, 2022 • 5 tweets • 2 min read
I’m quite sure it was not hyper-caution on COVID policy that got these guys recalled If you are wondering what really happened, start here
Jan 30, 2022 • 7 tweets • 1 min read
Lotta red Anyone else hearing the “Beat LA” as loudly and clearly as I am?
Jan 29, 2022 • 5 tweets • 1 min read
It's been a while since I've bragged on Ruthie so if you're not into that kind of thing just mute me.

Meanwhile, during the pandemic, since basketball was a challenge, she took up crew. She got waaaay into it and very nearly quit basketball as a result But she ultimately decided to play for her high school, where she's now a 9th grader. The girls' varsity basketball team is definitely in a rebuilding phase. They have really struggled, but they've also worked hard, and they do keep getting better (which is all you can ask)
Oct 5, 2021 • 9 tweets • 3 min read
If I understand correctly, one of the core tenets of the CIM is that fat gets trapped inside fat cells which leads to "internal starvation" and this causes overeating & obesity (and associated metabolic disease(s)) One of the things that has bothered me for a long time is that metabolic disease is actually associated with *inadequate* fat storage in fat cells. diabetes.diabetesjournals.org/content/51/9/2…
Oct 3, 2021 • 4 tweets • 1 min read
It is shocking that democracy survived the totalitarianism brought on by seat belt laws now 30 years ago freep.com/story/money/ca… I mean I am still not sure how to explain to my children that the people did not take to the streets over the intrusion of the government into our lives. That constant beeping reminder to buckle your seat belt is practically waterboarding
Sep 18, 2021 • 4 tweets • 1 min read
When does "potentially" become "absolutely 100% definitely certainly"? Of course anyone raised in the '70s and '80s will remember these genius ads:

"when it absolutely, positively has to be there overnight"

Sep 15, 2021 • 4 tweets • 1 min read
What a colossal waste of money San Francisco County will save Larry
Jun 25, 2021 • 11 tweets • 3 min read
Dave, I think we have beaten this topic to a pulp but lest anyone think I am insane or just being a mean bully, I wanted to remind you of this discussion we had over 2 years ago. It is a long thread and related to a podcast you did with Dr. Drew Here is the thread:

And here are screenshots of the relevant parts
Jun 14, 2021 • 37 tweets • 11 min read
Long thread on some new research. Sorry it is long and sorry it's about nutrition. Also I do some speculating at the end... New from outstanding team @UBC including @DrJonLittle @kaja_falkenhain @theloctor + @Dy1anLowe: a randomized trial comparing @ww_us or @getkeyto with weight loss at 12 weeks as primary endpoint:
onlinelibrary.wiley.com/doi/abs/10.100…
Jun 5, 2021 • 16 tweets • 3 min read
I guess I graduated from medical school 25 years ago. It got me thinking about what’s changed & what hasn’t.

In the past 25 years in medicine:

1) What has changed that you never expected to change?

2) What hasn’t changed that you expected would by now? I’ll start:

There are some obvious ones like communication. Cell phones barely existed in 1996. Email was just getting traction. Pagers were ubiquitous. We interacted with paper charts way more than we ever touched a computer. Video visits were some kind of Star Trek concept
Nov 5, 2020 • 16 tweets • 4 min read
Quick thoughts on the idea of there being a choice between lockdowns and dead bodies. I live in San Francisco. We had our first COVID cases here in early February. We have been conservative here, but hardly locked down. Restaurants have been open for outdoor dining. Bars now too Gyms and salons recently reopened. Many workplaces are back at less than 100% capacity. Public schools have been closed but private schools have been opening since September
Nov 4, 2020 • 4 tweets • 1 min read
4 years too early on this one And the fancy math is really just a victim of GIGO with lipstick

Nov 3, 2020 • 18 tweets • 3 min read
4 years ago I was over-confident but nervous. Today I am just excited Here is a thread from later in the day. It is interesting to see how the potential of Donald Trump as President was just a sick joke at that time. We now have the reality of the past 4 years. We will never get them back...

Oct 4, 2020 • 11 tweets • 1 min read
Everyone calm down. This Suburban comes with negative pressure (obviously) Image Also WTF is going on?
Oct 3, 2020 • 13 tweets • 3 min read
I've done a number of interviews this week about TREAT jamanetwork.com/journals/jamai….

One of the most frequent questions I get asked is:

"How do you explain that time-restricted eating worked for all those celebrities?"

I'm dead serious that I've been asked this (several times) I usually remind the interviewer that TRE worked for me. I lost weight. But then I also remind that people tend to lose weight (in the short-term) doing a lot of things. It is one of the reasons we do randomized trials
Sep 28, 2020 • 32 tweets • 9 min read
1/ Today is Yom Kippur. Many Jewish people are fasting. I am not

But I still want to talk about fasting… 2/ Today we are finally publishing the results of a study on Time Restricted Eating (TRE), which is a form of intermittent fasting. The study is called the TREAT Study. More on that later…
Sep 23, 2020 • 4 tweets • 1 min read
I don't think there is a way I can watch this too many times A little more color

washingtonpost.com/politics/2020/…