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George Alba Profile picture
George Alba
@galbamd
pulmonary & ICU doc @mghmedicine @harvardpulm | aspiring scientist @harvardmed | husband to @lucyschulson | dad to pen & izzy | opinions my own
Feb 2, 2021 • 20 tweets • 22 min read
1/20

New in @ATSBlueEditor, the culmination of over 4 years of work in the @bradleymaron lab, in which we identify that #NEDD9 is a hypoxia-regulated pulmonary endothelial protein that directly binds activated platelets to promote pulmonary thrombosis.
atsjournals.org/doi/10.1164/rc… 2/20

The @bradleymaron lab previously discovered that the malignancy protein #NEDD9 promotes endothelial fibrosis by regulating collagen synthesis in human pulmonary artery endothelial cells (HPAECs), which could be targeted to inhibit #PAH in vivo.
stm.sciencemag.org/content/10/445…