I used Matlab for image processing for years. Tried to switch to Python 10 years ago but too many tools were still missing. Tried again 5 years ago and haven't touched Matlab ever since! The combination scikit-image + @ProjectJupyter was a real game-changer! A few more things: On top of the great classics scientific stack (#numpy, #scipy, #pandas, #matplotlib) there's an entire ecosystem of new tools to handle all sorts of complex problems. E.g. #napari to visualize and annotate multi-dimensional data. @dask_dev to handle very large images.